Ionwerks, Inc.

The Texas A&m University System

Other

University of California

The United States of America As Represented by the United States

J Albert Schultz

Thomas F Egan

Michael V Ugarov

Steven Ulrich

Marc Gonin

Katrin Fuhrer

Kelley L Waters

Agnès Tempez

Valeri V Raznikov

Ernest K Lewis

Valerie E Vaughn

Michael I McCully

William Aaron Burton

Vladislav V Zelenov

David H Russell

John A McLean

Marina O Raznikova

Yvon Le Beyec

Valeriy V Raznikov

Dieter M Gruen

Howard K Schmidt

Alan R Krauss

Michael Ugarov

Alexander R Pikhtelev

Gennadiy Savenkov

Kimberly A Prather

Kent J Gillig

Agnes Tempez

Valeri Raznikov

Vincent Scott Smentkowski

Serge D Negra

Serge Della-Negra

John C Holecek

Valentin A Tarasenko

Hiroshi Furutani

Kelly L Waters

Serge Della University Paris Sud Negra

Yvon University Paris Sud Le Bayec

Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.

Nanoparticulate assisted nanoscale molecular imaging by mass spectrometry

Nanoparticulate assisted nanoscale molecular imaging by mass spectrometery

Described is an analytical method and apparatus for counting and measuring the flight time of secondary electrons, secondary ions and neutrals, scattered ions and/or neutrals and for correlating coincidences between these while maintaining a continuous un-pulsed, micro-focused, primary particle beam for impinging a surface for purposes of microprobe imaging and microanalysis.

Time-of-flight spectrometry and spectroscopy of surfaces

Nonoparticulate assisted nanoscale molecular imaging by mass spectrometery

The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.

Post-ionization of neutrals for ion mobility oTOFMS identification of molecules and elements desorbed from surfaces

The present invent provides a particle detector for counting and measuring the flight time of secondary electrons and scattered ions and neutrals and to correlate coincidences between these and backscattered ions/and neutrals while maintaining a continuous unpulsed microfocused primary ion beam for impinging a surface. Intensities of the primary particle scattering and secondary particle emissions are correlated with the position of impact of the focused beam onto a materials surface so that a spatially resolved surface elemental and electronic structural mapping is obtained by scanning the focused beam across the surface.

Time-of-flight mass spectrometry of surfaces

Time-of-flight mass spectrometer instruments are disclosed for monitoring fast processes with large dynamic range using a multi-threshold TDC data acquisition method or a threshold ADC data acquisition method. Embodiments using a combination of both methods are also disclosed.

Fast time-of-flight mass spectrometer with improved data acquisition system

The content of the invention comprises a concept of reactor for isolated ion transformations induced by collisions with neutral species. This reactor is also an interface between mobility cell and orthogonal injection TOFMS based on supersonic adiabatic gas flow with variable controlled composition directed along the axis of a multipole ion guide with sectioned rods for possibility of creating of controlled distributions of RF, DC and AC rotating fields.

Neutral/ion reactor in adiabatic supersonic gas flow for ion mobility time-of-flight mass spectrometry

The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.

Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording

Fast time-of-flight mass spectrometer with improved dynamic range

A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms.

Multiplex data acquisition modes for ion mobility-mass spectrometry

Growing community of inventors

Houston, TX, United States of America

J Albert Schultz