Freie Universitat Berlin

Forschungsverbund Berlin E.v.

Max-delbruck-centrum Fur Molekulare Medizin

Jörg Rademann

Walter Birchmeier

Stefan Wagner

Eric Nawrotzky

Matteo Accorsi

Klaus Hellmuth

Christoph Arkona

Ee Lin Wong

Boo Geun Kim

Stefanie Grosskopf

It is provided a pentafluorophosphate derivative according to general formula (I): or a pharmaceutically acceptable salt or solvate thereof. Thereby, Rand Rdenote independently from each other H or F; Rdenotes H, a C-Calkyl optionally substituted by a hydrocarbon chain comprising an amide function and/or a carboxyl function, or by a substituent chosen from the group consisting of alkyl, alkylamino, alkylaminocarboxy, carboxy, alkoxycarbonyl, hydroxy, N-morpholino, N-morpholinoalkyl, N-morpholinocarbonyl, N-methyl-N-piperazinyl, N-methyl-N-piperazinylalkyl, N-methyl-N-piperazinylcarbonyl, and sulfo, an optionally substituted C-Ccycloalkyl, or an optionally substituted C-Caryl, wherein a hydrocarbon chain of the alkyl, the cycloalkyl or the aryl can be interrupted by one or more oxygen, sulfur and/or nitrogen atoms; and M denotes any cation; with the proviso that at least one of Rand Rdenotes F, if Rdenotes H.

Pentafluorophosphate derivative, its uses and an appropriate manufacturing method

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Berlin, Germany

Jörg Rademann