Sumitomo Dainippon Pharma Co., Ltd.

Dainippon Sumitomo Pharma Co., Ltd.

Izumi Sasaki

Hidefumi Yoshinaga

Yoko Takahashi

Tomohiro Toyoda

Itaru Natsutani

Yoshihiro Horiuchi

Hiroaki Fujiwara

Hitoshi Suda

Kiyoto Sawamura

Mitsutaka Iwata

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HTantagonistic action (antidepressive and anxiolytic effects), in particular, 5-HTinverse agonistic action comprising Compound (1): 

Pyrazole compound

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HTantagonistic action (antidepressive and anxiolytic effects), in particular, 5-HTinverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HTantagonistic action (antidepressive and anxiolytic effects), in particular, 5-HTinverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereofwherein R, R, Rand Rare independently hydrogen or Calkyl etc.; Ris Calkyl or &#x2014;(CRR)-E; R, R, Rand Rare independently hydrogen, fluorine or Calkyl; A is Caryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is Ccycloalkyl or Caryl etc.; L is oxygen, sulfur or &#x2014;NR&#x2014;; n is 1, 2 or 3; Ris hydrogen or Calkyl etc.; and X is hydrogen or halogen etc.

Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is Carylene, etc.; R, Rand Reach independently is a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, etc.; Ris an optionally substituted Caryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted Caralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.) 

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Chuo-ku, Japan

Izumi Sasaki