Wisconsin Alumni Research Foundation

Izabela Sibliska

Hector Floyd Deluca

Lori A Plum

Margaret Clagett-Dame

Rafal R Sicinski

Rafal Barycki

Katarzyna Plonska-Ocypa

Katarzyna M Barycka

This invention discloses 2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-19-nor-vitamin Dand (20R)-25-hydroxy-2-methylene-19-nor-vitamin D, as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. Although these compounds have relatively low calcemic activities they may also be useful in the treatment of bone diseases due to their ability to act as prodrugs in vivo.

2-methylene-19-nor-vitamin D analogs and their uses

Growing community of inventors

Warsaw, Poland

Izabela Sibliska