Chugai Seiyaku Kabushiki Kaisha

Perseus Proteomics Inc.

Iwao Ohizumi

Tadanori Mayumi

Shinsaku Nakagawa

Yasuo Tsutsumi

Yukio Ito

Tatsuhiko Kodama

Hiroyuki Aburatani

Takao Hamakubo

Kiyotaka Nakano

Ryoichi Saitoh

Susumu Tokita

Yutaka Midorikawa

Provided is a method for diagnosing cancer by detecting a novel cancer marker. Cancer can be diagnosed by detecting soluble glypican 3 in a test sample.

Method for diagnosing cancer by detecting GPC3

The present inventors extensively studied and found that an antibody binding to PepT has cytotoxic activity and inhibits cell growth. These results suggest that an antibody binding to PepT, particularly an antibody having a cytotoxic activity, can be used as a cell growth inhibitor, for example, in treating and preventing cancer.

Cell growth inhibitor containing anti-PepT antibody

A monoclonal antibody which recognizes an antigen of a molecular weight of 40 kD or 80 kD on the surface of tumor vessel endothelial cells, hybridomas producing the monoclonal antibody, pharmaceutical agents comprising the monoclonal antibody, as well as pharmaceutical or diagnostic agents comprising a conjugate of the monoclonal antibody and another conjugating molecule.

Tumor vessel endothelial cell-binding monoclonal antibodies

A monoclonal antibody which recognizes an antigen of a molecular weight of 40 kD or 80 kD on the surface of tumor vessel endothelial cells, hybridomas producing said monoclonal antibody, pharmaceutical agents comprising said monoclonal antibody, as well as pharmaceutical or diagnostic agents comprising a conjugate of said monoclonal antibody and another conjugating molecule.

Monoclonal antibodies recognizing antigens on the surface of endothelial cells of tumor vessel

Growing community of inventors

Shizuoka, Japan

Iwao Ohizumi