Kyowa Hakko Kirin Co., Limited

Kyowa Kirin Co., Ltd.

Iwao Chujo

Arata Yanagisawa

Takamasa Sugita

Atsushi Tada

Masashi Aoki

Masashi Taga

Akihiro Mimura

Tsutomu Matsumura

Koji Hagihara

Masahiro Hoshikawa

Provided is a production method of a thiazole derivative represented by the formula (I), which has an adenosine Areceptor antagonistic action and is useful as a therapeutic agent for, for example, Parkinson's disease, sleep disorder, analgesic resistance to opioid, migraine, movement disorder, depression, anxiety disorder and the like. Also provided is a production method of a compound represented by the formula (C), which contains (i) a step of reacting a compound represented by the formula (A) and a compound represented by the formula (B), and the like: (wherein Rrepresents furyl, R, Rand Rare the same or different and each represents lower alkyl or aryl, Rrepresents pyridyl or tetrahydropyranyl, and Xrepresents halogen).

Production method of thiazole derivative

The present invention provides a method for producing an indazol-3-ylmethyl phosphonium salt represented by Formula (IV): [wherein X represents halogen, OSOR(wherein Rrepresents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or OC(&#x2550;O)R(wherein Rhas the same meaning as the above R), or the like, and R, Rand Rmay be the same or different and each represents substituted or unsubstituted aryl or the like] or a salt thereof, which comprises reacting a compound represented by Formula (I): a compound represented by Formula (II):H&#x2014;X&#x2003;&#x2003;(II)(wherein X has the same meaning as defined above), and a compound represented by Formula (III): (wherein R, Rand Rhave the same meanings as defined above, respectively), and the like.

Method for producing indazol-3-ylmethyl phosphonium salt

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Chiyoda-ku, Japan

Iwao Chujo