Ecole Polytechnique Federale De Lausanne

Abionic Sa

Ecole Polytechnique Féderale De Lausanne (epfl)

Iwan Märki

Nicolas Durand

Theo Lasser

Annick Mayor

Stéphane Broillet

Yannick Fournier

Matthias GEISSBÜHLER

A method and device for multiplexing and calibrating rapid quantification of biomolecules present in a nanofluidic biosensor composed by a nanoslit. A novel concept defining multiple different local structured areas containing biomarkers. Local structured areas can also be structured to decrease the biomarkers density in the nanoslit. Such enables the multiplexed quantification biomolecular interactions of interest in the same nanofluidic biosensor.

Method and device for bioassays

A method and device for the rapid quantification of biomolecules () present in a nanochannel () is claimed. In particular, the present invention relates to a novel concept of liquid actuation and selectively functionalized surfaces in a nanochannel that create a concentration gradient of transitory immobilized biomolecules () across the nanochannel. The present concept enables the quantification of biomolecular interactions of interest ().

Rapid quantification of biomolecules in a selectively functionalized nanofluidic biosensor and method thereof

A method and device for the rapid detection of biomolecules () diffusing in a nanometer-confined slit () is claimed. In particular, the present invention relates to a novel concept of fluidic side apertures () that facilitates the filling of the device, the surface coating with biomolecules and that measures the affinity between fluorescently labeled biomolecules in aqueous solution with other biomolecules immobilized on surfaces.

Nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods

A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing one or several arrays of biosensors, said system furthermore comprising a reader unit for optical excitation and detection.

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Yverdon, Switzerland

Iwan Märki