Institut Pasteur

Other

Columbia University

Institut National De La Sante Et De La Recherche Medicale

The Rockefeller University

Ivo Boneca

Gabriela Chiosis

Philippe J Sansonetti

W Clark Still

Stephen Girardin

Dana Philpott

A method for modulating Nod1 activity wherein said method comprises the steps of providing cells expressing a functional Nod1; and bringing said cells into contact with a molecule related to compositions comprising a molecule related to MTP and use of a molecule related to MTP for modulating inflammation and/or apoptosis.

Method for modulating Nod1 activity, use of a MTP related molecule for modulating Nod1 activity, and therapeutic applications thereof

A method for modulating Nod 1 activity wherein said method comprises the steps of providing cells expressing a functional Nod 1; and bringing said cells into contact with a molecule related to compositions comprising a molecule related to MTP and use of a molecule related to MTP for modulating inflammation and/or apoptosis

The present invention relates to pyrrolidine compounds of the general structure:where n is an integer 1-6 and R is hydrogen or a Cto Cstraight chain or branched alkyl group, and wherein when n=1, R=CHor H, useful for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond on the cell wall peptide precursors of the bacteria.

Method of re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide

The present invention relates a method for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond in the cell wall peptide precursors of the bacteria which comprises using an antibacterial amount of vancomycin or a homolog of vancomycin and an amount of an agent effective to selectively cleave the ester bond so as to thereby re-sensitize vancomycin resistant bacteria.

Growing community of inventors

Vitry sur Seine, France

Ivo Boneca