Ceskoslovenska Akademie Ved

Ivo Blaha

Tomislav Barth

Michal Lebl

Hans Vilhardt

Jana Skopkova

Jirina Slaninova

Zdenko Prochazka

Miroslava Zertova

Jiri Velek

Lenka Maletinska

Analogues of 8-D-homoarginine vasopressin were prepared with the general formula ##STR1## where X is L-O-methyltyrosine, L-p-ethylphenylalanine, D-p-ethylphenylalanine, L-p-methylphenylalanine or D-methylphenylalanine and R is cysteine or .beta.-mercaptopropionic acid. These vasopressin analogues exhibited an increased affinity to uterus receptors for oxytocin, where they acted as ocytocin antagonists. Moreover, the analogues of deamino vasopressin have a significantly reduced antidiuretic activity in comparison with [8-D-arginine]vasopressin.

Analogues of 8-D-homoarginine vasopressin

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Prague, Czechia

Ivo Blaha