The University of British Columbia

Provincial Health Services Authority

Ivica Bratanovic

François Bénard

Chengcheng Zhang

Kuo-Shyan Lin

Zhengxing Zhang

Lei Wang

There is provided peptidic compounds of Formula I, A or B(R-[linker]-R-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-ψ-Xaa-NH). Xaais D-Phe, Cpa, D-Cpa, Nal, D-Nal, 2-Nal, or D-2-Nal; Xaais Asn, Gln, Hse, Cit or His. Xaais Trp, Bta, Trp(Me), Trp(7-Me), Trp(6-Me), Trp(5-Me), Trp(4-Me), Trp(2-Me), Trp(7-F), Trp(6-F), Trp(5-F), Trp(4-F), Trp(5-OH), or αMe-Trp. Xaais Ala or Ser. Xaais Val, Cpg, or Tle. Xaais Gly, NMe-Gly, or D-Ala. Xaais His or NMe-His. Xaais Leu or Phe. Xaa-NHis a C-terminally amidated amino acid residue selected from Pro, 4-oxa-L-Pro, MeThz, or Thz. ψ represents a peptide bond or reduced peptide bond joining Xaato Xaa. Ris 1-5 radiolabeling groups. There is also provided the use of such compounds as imaging agents or therapeutic agents.

Growing community of inventors

Port Moody, Canada

Ivica Bratanovic