Glaxosmithkline Istrazivacki Centar Zagreb D.o.o.

Fidelta D.o.o.

Selvita D.o.o.

Ivaylo Jivkov Elenkov

Milan Mesic

Gordon Saxty

Mladen Mercep

Dijana Pesic

Stribor Markovic

Antun Hutinec

Boska Hrvacic

Goran Kragol

Dinko Ziher

Andrea Fajdetic

Visnja Poljak

Renata Rupcic

Zorica Marusic Istuk

Sanja Kostrun

Maja Matanovic Skugor

Ivica Malnar

Kristina Butkovic

Lidija Simicic

Andreja Cempuh Klonkay

Marko Duksi

Anita Filipovic

Mirjana Bukvic

Ivana Ozimec Landek

The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.

Seco macrolide compounds

The invention relates to novel compounds of the formula (I) including all their tautomers, to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof, and to processes and reactive intermediates for the preparation of the compounds of the formula (II) including all their stereoisomers and tautomers to the use of the compounds of the formula (II) as suitable precursors for the preparation of the compounds of the formula (I) as well as to use of the compounds of the formula (I) and of the compounds of the formula (II) as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diesases and conditions in humans.

Substituted furochromenes, preparation thereof and their antiinflammatory action

The present invention relates to novel compounds of the formula (I) including all stereoisomers and tautomers thereof, to the pharmaceutically acceptable salts and solvates thereof, to the processes and reactive intermediates for their preparation and to their use in the prophylaxis and treatment of asthma and other inflammatory diseases and/or conditions in humans.

Substituted furochromene compounds of antiinflammatory action

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Zagreb, Croatia

Ivaylo Jivkov Elenkov