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Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr

Institu Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr

Institut Organicheskogo Sinteza Akademii Nauk Ssr

Ivars Y Kalvinsh

Maris M Veveris

Edmund Y Lukevits

Gunar A Bremanis

Irene B Antsena

Anatoly S Birman

Elena B Astapenok

Valeryans Y Kauss

Valdis D Mikazhan

Edvards E Liepinsh

Marina L Erenshtein

Petr T Trapentsier

Alexei V Vinogradov

Oleg N Akifiev

Inna I Makarova

Petr T Trapentsiers

Boris Z Simkhovich

Gennady I Podoprigora

Ma/Ya G Pshennikova

Solomon A Giller, Deceased

Yazep Y Spruzh

Yan Y Latvietis

Felix Z Meerson

Paul P Anderson

Georgy V Barmotin

Peter T Trapentsier

Nurlan Abdikaliev

Anatoly Eremeev

Edit A Pule

Valentina G Semenikhina

Edvard E Liepinsh

The present invention relates to the art of organic chemistry. The novel compounds - ethyl-3-(2-ethyl-2,2-dimethylhydrazinium)-propionate salts have the general formula: ##STR1## wherein X is Cl, Br, I. The compounds of the present invention possess an antiarrhythmic effect.

Ethyl-3-(2-ethyl-2,2-dimethylhydrazinium)-propionate salts to treat

Novel compounds, viz. 3-(2,2,2-trisubstituted hydrazinium) propionates have the following general formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are an alkyl, a substituted alkyl, a substituted or unsubstituted aryl, an aralkyl or an unsaturated alkyl;

3-(2,2,2-trisubstituted hydrazinium) propionates

The pharmaceutical composition possessing antitumor activity against tumors susceptible to 2-carbamoylaziridine which consists of a therapeutically efficaceous quantity of 1-H-2-aziridinecarbonic acid derivative having the formula ##STR1## where R is NH.sub.2 and a pharmaceutically suitable solvent or filler. The pharmaceutical composition possesses a high activity against tumors susceptible to 2-carbamoylaziridine, a wide spectrum of antitumor effect and low toxicity (LD.sub.50 within the range of 3,000 and 3,500 mg/kg. The invention is also a method for treating malignant tumors susceptible to 2-carbamoxylaziridine by administration of 2-carbamoyl-aziridine.

Pharmaceutical composition and method for treating tumors susceptible to

Substituted 3-hydrazinopropionates comprising compounds of the general fola: ##STR1## wherein R.sup.1, R.sup.2 =H, an alkyl, a substituted alkyl, hydroxycarbonyl, alkoxycarbonyl, an aryl, an aralkyl, an unsaturated alkyl, a substituted aryl or a substituted aralkyl: ##STR2## wherein R.sup.7, R.sup.8 =H, an alkyl, an unsaturated alkyl, an aralkyl, an aryl, a substituted alkyl,

Substituted 3-hydrazinopropionates

A novel pharmaceutical preparation for the treatment of hypertensive disease and myocardial infarction, which comprises as an active ingredient, (1,1-dimethyl-3-oxopyrazolidin-1-io-4-yl)acetate of the following formula: ##STR1## and a pharmaceutically acceptable vehicle.

Pharmaceutical preparation for the treatment of hypertensive disease and

The novel compound according to the invention 3-(2,2,2-trimethylhydrazinium)-propionate has the general formula:

3-(2,2,2-Trimethylhydrazinium)propionate and method for the preparation

A pharmaceutical composition for the treatment of cardio-vascular diseases comprising 3-(2,2,2-trimethylhydrazinium) propionate dihydrate of the following formula:

Treatment of cardio-vascular diseases with

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Ivars Y Kalvinsh