Gruenenthal Gmbh

Grunenthal Gmbh

Ivars Graudums

Elmar Josef Friderichs

Werner Winter

Helmut Heinrich Buschmann

Klaus Schiene

Hagen-Heinrich Hennies

Achim Kless

Oswald K Zimmer

Petra Bloms-Funke

Peter Jansen, Deceased

Bernd Sundermann

Werner Guenter Englberger

Derek John Saunders

Wolfgang Werner Strassburger

Claudia Katharina Puetz

Dagmar Kaulartz

Carsten Griebel

Wolfgagn Werner Strassburger

Ernst Frankus

Sabine Reinardy

Elmar Josef Friederichs

Saturated and unsaturated heteroarylcycloalkylmethyl-amine compounds corresponding to formula I, processes for their preparation, pharmaceutical formulations comprising these compounds and the use of saturated and unsaturated heteroarylcycloalkylmethyl-amines for the preparation of pharmaceutical formulations. pharmaceutical formulations and related methods of treatment or prophylaxis of certain condition, especially depression and/or pain, are also disclosed.

Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants

The invention relates to substituted amino compounds, to processes for their preparation, to pharmaceutical formulations containing these compounds and to the use of these substances in the preparation of pharmaceutical formulations, especially for the treatment or inhibition of depression, anxiety, pain and urinary incontinence, and to related methods of treating or inhibiting these disorders.

Substituted amino compounds as 5-HT/NA uptake inhibitors

1-phenyl-2-dimethylaminomethyl-cyclohexan-1-ol compounds, methods of preparing them and the use of these compounds in drugs are described.

1-phenyl-2-dimenthylaminomethyl-cyclohexan-1-ol compounds as

A method of preparing the enantiomers of O-demethyltramadol and the use of the enantiomers as pain-killing drugs are described.

Method of preparing the enantiomers of O-dimethyltramadol

A method of separating the racemate of tramadol is disclosed.

Method of separating the racemate of tramadol

The invention relates to new lactam compounds, pharmaceutical compositions containing them (especially those for oral or rectal application) and to processes for the preparation of these compounds and compositions. The new compounds have the general formula ##STR1## wherein X represents a straight or branched alkyl radical with 1 to 4 carbon atoms, preferably a methyl group. The new compounds of formula (I) have sedating-tranquilizing properties. In higher dosages some of them also act as hypno-anesthetics. Moreover the derivative in which X represents the methyl group has anticonvulsant activities. The valuable compounds of formula (I) are prepared in a manner known per se e.g. by reacting an 3-alkyl-3-halogen-2-oxopiperidine (the alkyl having 1-4 carbon atoms) with a metal derivative of 2,3-dihydro-3-oxo-1,2-benzisothiazoldioxid-(1,1) or by reacting an 3-alkyl-3-amino-2-oxopiperidine with o-sulfobenzoic acid dichloride or dibromide or with an o-halomercaptobenzoylhalide, followed by oxydation. Other processes known per se, such as cyclizations to form lactam rings, are also suitable for the preparation of the compounds of formula (I).

Lactams Compositions and pharmaceutical methods of use

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Stolberg, Germany

Ivars Graudums