Alnylam Pharmaceuticals, Inc.

Arrowhead Pharmaceuticals, Inc.

Genzyme Corporation

Ivanka Toudjarska

Brian R Bettencourt

David A Bumcrot

Stuart Milstein

Jared Gollob

Kallanthottathil G Rajeev

Martin A Maier

Klaus Charisse

Satyanarayana Kuchimanchi

Gregory Hinkle

John M Maraganore

Jan Weiler

Shanthi Ganesh

Elizabeth George

Jonathan Solomon

Emily Thomas

Jennifer Tullai

Akin Akinc

Dinah Wen-Yee Sah

Alfica Sehgal

Donald Foster

Dieter Huesken

Muthiah Manoharan

Markus Warmuth

Akshay Vaishnaw

Frank Peter Stegmeier

Greg Hinkle

Christina Gamba-Vitalo

Kalyani Gampa

Mark Stump

Dieter Heusken

Zainab Jagani

Muthiah Monaharan

Michael Jr Schlabach

Earl Mcdonald

Brian Bettencourt

The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a G-alpha q subunit (GNAQ) of a heterotrimeric G gene, and methods of using the dsRNA to inhibit expression of GNAQ.

GNAQ targeted dsRNA compositions and methods for inhibiting expression

The present disclosure relates to methods of treating EPAS1-related diseases such as cancer, metastases, astrocytoma, bladder cancer, breast cancer, chondrosarcoma, colorectal carcinoma, gastric carcinoma, glioblastoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, lung adenocarcinoma, neuroblastoma, non-small cell lung cancer, melanoma, multiple myeloma, ovarian cancer, rectal cancer, renal cancer, clear cell renal cell carcinoma (and metastases of this and other cancers), gingivitis, psoriasis, Kaposi's sarcoma-associated herpesvirus, preeclampsia, inflammation, chronic inflammation, neovascular diseases, and rheumatoid arthritis, using a therapeutically effective amount of a RNAi agent to EPAS1.

Organic compositions to treat EPAS1-related diseases

The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the TMPRSS6 gene, and methods of using such dsRNA compositions to inhibit expression of TMPRSS6.

Compositions and methods for inhibiting expression of TMPRSS6 gene

The invention relates to double-stranded ribonucleic acid (dsRNA) targeting a PROC gene, and methods of using the dsRNA to inhibit expression of PROC.

Compositions and methods for inhibition of expression of protein C (PROC) genes

The present disclosure relates to methods of treating EPAS1-related diseases such as cancer, metastases, astrocytoma, bladder cancer, breast cancer, chondrosarcoma, colorectal carcinoma, gastric carcinoma, glioblastoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, lung adenocarcinoma, neuroblastoma, non-small cell lung cancer, melanoma, multiple myeloma, ovarian cancer, rectal cancer, renal cancer, clear cell renal cell carcinoma (and metastases of this and other cancers), gingivitis, psoriasis, Kaposi's sarcoma-associated herpesvirus, preemclampsia, inflammation, chronic imflammation, neovascular diseases, and rheumatoid arthritis, using a therapeutically effective amount of a RNAi agent to EPAS1.

The present disclosure relates to methods of treating EPAS1-related diseases such as cancer, metastases, astrocytoma, bladder cancer, breast cancer, chondrosarcoma, colorectal carcinoma, gastric carcinoma, glioblastoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, lung adenocarcinoma, neuroblastoma, non-small cell lung cancer, melanoma, multiple myeloma, ovarian cancer, rectal cancer, renal cancer, clear cell renal cell carcinoma (and metastases of this and other cancers), gingivitis, psoriasis, Kaposi's sarcoma-associated herpesvirus, preemclampsia, inflammation, chronic inflammation, neovascular diseases, and rheumatoid arthritis, using a therapeutically effective amount of a RNAi agent to EPAS1.

The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia.

Serpinc1 iRNA compositions and methods of use thereof

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Medford, MA, United States of America

Ivanka Toudjarska