Drug Innovation & Design, Inc.

Paratek Pharmaceuticals, Inc.

Ivan Yanachkov

Arnold Glazier

Milka Yanachkova

Mark L Nelson

Roger Frechette

Mohamed Y Ismail

Beena Bhatia

Todd Bowser

Oak K Kim

Tadeusz Warchol

Peter Viski

Laura Honeyman

Joel Berniac

Kwasi Ohemeng

Haregewein Assefa

Atul K Verma

Jackson Chen

Paul Abato

Victor Amoo

Rachid Mechiche

N Laxma Reddy

Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.

Amino-methyl substituted tetracycline compounds

Disclosed are novel prodrugs represented by the following structural formula;

Acyclovir diester derivatives

Disclosed are novel prodrugs represented by the following structural formula:

Methods of preparing acyclovir prodrugs

Disclosed are novel prodrugs represented by the following structural formula: ##STR1## Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

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Newton, MA, United States of America

Ivan Yanachkov