Xenon Pharmaceuticals Inc.

Genentech, Inc.

Ivan William Hemeon

Sultan Chowdhury

Christoph Martin Dehnhardt

Brian Salvatore Safina

Michael Edward Grimwood

Thilo Focken

Shaoyi Sun

Alla Yurevna Zenova

Daniel P Sutherlin

Qi Jia

Michael Scott Wilson

Jean-Christophe Andrez

Paul Robert Bichler

Daniel Fred Ortwine

Shannon Marie Decker

Abid Hasan

Tao Sheng

Wei Gong

Jun M Li

Philippe Bergeron

Steven McKerrall

Zhiguo Liu

Jiuxiang Zhu

Andrew D White

Chien-An Chen

Jianmin Fu

Tarek Suhayl Mansour

Chien-an Chen

Dan Sutherlin

Jun Li

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

The invention provides compounds having the general formula I:  and pharmaceutically acceptable salts thereof, wherein the variables R, n, ring A, X, L, m, X, R, R, R, R, X, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables R, R, n, ring A, X, L, m, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Substituted benzamides useful as sodium channel blockers

The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X, L, subscript m, X, ring D, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

N-substituted benzamides and methods of use thereof

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables R, subscript n, ring A, X, L, subscript m, X, B, R, R, R, R, Rand Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having the general formula: [insert formula (I)] (I) and pharmaceutically acceptable salts thereof, wherein the variables R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Substituted triazolopyridines and methods of use thereof

This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Growing community of inventors

Burnaby, Canada

Ivan William Hemeon