Ceskoslovenska Akademie Ved

Spofa, Spojene Podniky Pro

Vyzkumny Ustav Pro Farmacii a Biochemii

Spojene Podniky Pro Zdravotnickou Vyrobu

Ivan Krejci

Evzen Kasafirek

Milan Pesak

Antonin Sturc

Arnost Pospisil

Jiri Vanzura

Jiri Krepelka

Tomislav Barth

Karel Jost

Antonin Dlabac

Linda Servitova

Alena Machova

Alena Roubalova

Martin Valchar

Jana Skopkova

Miroslav Rybak

Frantisek Brtnik

Vaclav Plaisner

Antonin Struc

Jirj Kohout

Libuse Korbova

Jirina Cizkova

Pavel Hrbas

Michal Bartik

Bela Kupkova

Zdenek Hlinak

Evzen Krepela

Karel Dobrovsky

The present application is directed to a method of treating central nervous system disorders originating as a consequence of head injury or brain ischemia. The method comprises administering an effective amount of cyclo-(L-alanyl-1-amino-1-cyclopentane carbonyl) to treat a central nervous system disorder in a mammalian organism in need of such treatment. The administration may be conducted either orally or parenterally.

Neuroprotective composition for preventing or treating of central

A cell-protective composition for preventing or treating of a peptic ulcer due to topical endogenous lesion of gastric or duodenal mucous membrane comprises as a physiologically active component the cyclo-(1-alanyl-amino-1-cyclopentanecarbonyl)cyclodipeptide. The subject composition is designated for administration by oral or parenteral route. It is substantially non-toxic and well tolerated, and acts beneficially, even at low dosage level.

Cell-protective composition for preventing or treating of peptic ulcer

Peptide ester and amide derivatives of the general formula I: ##STR1## in which X is H or an acyl, A and B are structurally defined amino acid residues, n is an integer of from 1 to 3, R.sup.1 is H or a lower alkyl and either R.sup.2 or C is a defined optionally modified amino acid residue and the other is a lower alkoxyl, an amino group or a direct chemical bond, are converted under physiologic conditions, by enzymic hydrolysis in pathologically altered tissues and subsequent spontaneous cyclization, into pharmacodynamically active spirocyclic peptide derivatives of the general formula III: ##STR2## in which R.sup.3 and R.sup.4 are H atoms, optionally substituted alkyl groups or jointly an aliphatic chain forming preferably a 2,5- piperazinedione ring, and hence can act as pro-farmaca (drug precursors) of prolonged biological effect.

Peptide derivatives and processes for their preparation

Vasopressin analogs of the formula ##STR1## wherein R.sup.1 is H, R.sup.2 is CH.sub.2 S and R.sup.3 is D-Arg,

Analogs of vasopressin

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Prague, Czechia

Ivan Krejci