University of Pennsylvania

California Institute of Technology

Ivan Julian Dmochowski

James H Eberwine

Teresa L Rapp

Julianne C Griepenburg

Jai-Yoon Sul

Julia Richards

Brittani Ruble

Qian Wei

Sean B Yeldell

Jennifer M Singh

Jaehee Lee

Ditte Lovatt

Michael J Therien

Harry B Gray

Jonathan James Wilker

Daniel A Hammer

Brian R Crane

Jay R Winkler

Yanfei Wang

Benjamin W Roose

XinJing Tang

Gregory Patrick Robbins

Masaya S Jimbo

Serge Zemerov

Neha P Kamat

Nicholas Kuzma

Zhuangyu Zhao

P Aru Hill

Aru P Hill

Jennifer M Chambers

Alexander Robert Dunn

Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.

Transcriptome in vivo analysis (TIVA) and transcriptome in situ analysis (TISA)

The present invention relates to compositions and methods using protein reporters as imaging agents inXe NMR and MRI applications. It is described that bla and MBP are genetically-encoded proteins that induce a detectable chemical shift duringXe NMR, allowing for use as protein reporters in research and clinical applications.

Protein reporters for ultrasensitive detection methods

The present invention provides ruthenium-based photolinker compounds, caged molecules comprising the ruthenium-based photolinker compounds, and methods of use. In certain aspects, the compositions disclosed herein comprise an active domain conjugated to a ruthenium-based photolinker, such that irradiation of the photolinker exposes the active domain.

Ruthenium-based photolinkers and methods of use

Provided are compositions and methods that permit a hybrid nucleic acid-peptide molecule to enter a cell and when specifically activated within the cell, the molecule anneals to endogenous cellular RNA and permits the isolation of the RNA.

Transcriptome in vivo analysis

The invention provides compositions and methods that permit a hybrid nucleic acid molecule to enter a cell and when specifically activated within the cell, the molecule anneals to endogenous cellular RNA and permits the isolation of the RNA.

This invention relates to methods and compositions of oligonucleotide constructs having a photocleavable linker. Specifically, provided herein are methods and compositions utilizing a photocleavable linker, which when exposed to light modulates the expression of genes.

Photocleavable oligonucleotide and uses thereof

Provided are polymer vesicles comprising polymersomes, a radiofrequency absorbing moiety, a protein or a polysaccharide associated with the inner leaflet of the membrane and a therapeutic or diagnostic cargo. The invention also concerns the use of these polymer vesicles for selective electromagnetic energy-induced delivery of therapeutic or diagnostic agents.

Polymer vesicles for selective electromagnetic energy-induced delivery

This invention relates to enzyme-sensitive biosensors and methods and kits using the same. Specifically, the invention relates to methods, systems and kits for the detection of enzymes using the chemical shift observed in an isotope complexed to the biosensor resulting from a change in the biosensor as the result of the enzyme's activity.

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This invention relates to biosensors with improved solubility and affinity to a noble element. Specifically, the invention relates to methods and systems for the detection of target entities using the signal observed in a noble element complexed to the biosensor.

Tri-functionalized cryptophane biosensors

Methods and compositions for detecting and characterizing target biomolecules using sensitizer-linked substrate molecules are disclosed. High throughput screening assays and therapeutic applications of the inventions are also included 

Detection of biomolecules by sensitizer-linked substrates

Growing community of inventors

Philadelphia, PA, United States of America

Ivan Julian Dmochowski