Università Degli Studi Di Trieste

Biopolife Srl

Ivan Donati

Sergio Paoletti

Marco Bosco

Andrea Travan

Gianluca Turco

Marina Diolosa'

Roberto Di Lenarda

Eleonora Marsich

Massimiliano Borgogna

Lorenzo Breschi

Milena Cadenaro

Disclosed are adducts of boric acid and chitosan wherein the amino groups of the D-glucosamine units are bonded to residues of polyol or alditol oligosaccharides, the molar ratio between boric acid and the repeating chitosan unit ranging between 0.001 and 4.

Soluble adducts of boric acid or derivatives and precursors thereof with chitosan oligosaccharide derivatives

The present invention concerns the preparation of chemically modified derivatives of chitosan with acrylic groups and their use in the field of enamel-dentin adhesives. Chitosan derivatives have physical-chemical features (hydrophilicity, presence of electrical charges on the chain) which allow them to interact with the organic part of the demineralized tooth. At the same time, the acrylic groups incorporated in the polymer chain allow the formation of a covalent bond with the restorative material used in the dental field that is typically composed of acrylic resins. By combining the adhesion to the tooth surface and the bond with the restorative material, the chemically modified chitosan described herein is able to increase the lifespan of the dental restoration and can thus find use in the field of adhesives, in particular enamel-dentin adhesives.

Enamel-dentin adhesives based on chemically modified natural polysaccharides

Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behavior with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behavior renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.

Polymer mixtures of anionic and cationic polysaccharides and use thereof

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Sedegliano, Italy

Ivan Donati