Eli Lilly and Company

Ivan Collado Cano

Concepcion Pedregal Tercero

Alicia Marcos Llorente

James Allen Monn

Ana Belen Bueno Melendo

Beatriz Lopez De Uralde Garmendia

Luisa Maria Martin-Cabrejas

Jesus Ezquerra-Carrera

Maria Rosario Gonzalez Garcia

Alicia Marcos Liorente

Compounds of the formula (I) in which R, Rand Xhave the meanings given in the specification, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system 

Excitatory amino acid receptor modulators

Compounds of the formula (I) in which R is C allyl; C alkenyl; C alkynyl; phenyl-C alkyl or phenyl-C alkenyl; and salts and esters thereof, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system

Compounds of formula (I) in which R is halo-C alkyl; halo-C alkenyl; or (CH ) Y in which n is 1 or 2 and Y is OH, CN, N , OR , SH, S(O) R , S(O) H, NH , NHR , NR R , NHCOR , NO , CO H, CONHR , 1H-tetrazol-5-yl, 5-phenyltetrazol-2-yl or PO H ; R , R , R , R , R and R are each selected independently from C alkyl, aryl and aryl-C alkyl; R is selected from C alkyl, aryl, aryl-C alkyl, and 1H-tetrazol-5-yl, carboxy-(1-4C)alkyl and 1H-tetrazol-5-yl-C alkyl; and p is 0, 1, 2 or 3; or a salt or ester thereof, provided that R is not methoxymethyl, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.

Growing community of inventors

Madrid, Spain

Ivan Collado Cano