Inventprise, LLC

Ivan A Olave

Subhash V Kapre

The invention is directed to an oral vaccine composed of a micronized freeze-dried rotavirus particle suspension with buffering excipients in a non-aqueous liquid. This IVT-06 formulation has imparted heat stability by protecting the virus at temperatures of 30&#xb0; C. and 40&#xb0; C. for at least twelve months. Extrapolations from the 12-month stability data indicate a shelf life of more than two years at 30&#xb0; C., and six months at 50&#xb0; C. In addition, for ease of administration, the formulated dose has a volume of 0.5 mL.

Heat stable vaccines

The invention is directed to an oral vaccine composed of a micronized freeze-dried rotavirus particle emulsion with buffering excipients in a non-aqueous liquid. This IVT-06 formulation has imparted heat stability by protecting the virus at temperatures of 30&#xb0; C. and 40&#xb0; C. for at least twelve months. Extrapolations from the 12-month stability data indicate a shelf life of more than two years at 30&#xb0; C., and six months at 50&#xb0; C. In addition, for ease of administration, the formulated dose has a volume of 0.5 mL.

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Kirkland, WA, United States of America

Ivan A Olave