Impulse Dynamics Nv

Itzik Shemer

Nissim Darvish

Yuval Mika

Bella Felsen

Bella Felzen

Walid Haddad

Judith Kornfeld

Richardo Aviv

Yaakov Haham

According to a method and device for modulating intracellular calcium concentration in biological tissue, a stimulation probe is applied to the tissue, a non-excitatory stimulation pulse is generated, and the pulse is conveyed to the stimulation probe. In one embodiment concerning cardiac tissue, a stimulation probe is applied to a patient's heart, a signal is received from at least one sensor responsive to the patient's cardiac muscle activity, a non-excitatory stimulation pulse responsive to the signal is generated, and the pulse is conveyed to the stimulation probe.

Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue

Apparatus () for heart pacing with hemodynamic improvement, including one or more electrodes (), which convey electrical signals to respective cardiac muscle segments. Signal generation circuitry () applies an extended pacing signal (), having an overall duration greater than three times a chronaxie time, to the one or more electrodes so as to pace the heart. The signal preferably includes a train of a plurality of biphasic pulses, and has an amplitude at least three times as great as a threshold for pacing the heart, but not sufficient for cardioversion.

Pacing with hemodynamic enhancement

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Haifa, Israel

Itzik Shemer