Tel Aviv University

Ramot University Authority for Applied Research and Industrial Development Limited

Yeda Research and Develpment & Co. Ltd

Hochman, Nira

Hochman, Jacob

Ofek, Itzhak

Weiss, Ervin

Itzhak Ofek

Ervin Weiss

Yoel Kashman

Janina Goldhar

Nathan Sharon

Matityahu Fridkin

Haim Tsubery

Zichria Zakay-Rones

Jacob Hochman

Yael Houri-Haddad

Nira Hochman

Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing same useful in the treatment of bacteremia and/or septicemia following infection by gram negative bacteria administered alone or in combination with conventional antibiotics.

Compounds pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia

The present invention concerns the use as anti-viral agents of isolated fractions from berry juice of the plant genus. Two specific fractions are provided: (a) polymeric material having a molecular weight&#x2267;12,000; and (b) proanthocyanidins-containing fraction. Thus, the invention provides methods of treating a subject against a viral infection; the method comprises providing said subject with at least one of the above isolated fractions in an amount effective to prevent production of a viral infection in said subject. A specific and preferred viral infection according to the invention is an influenza virus infection.

Methods of treating viral infections using berry juice fractions

A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of theplant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight &#x2267;14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS.A andB; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and

Anti-microbial-adhesion fraction derived from vaccinium

A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight &gE;14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS.,A and,B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and

A non-food oral hygiene composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In a preferred embodiment the anti-aggregation fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight .gtoreq.14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; an NMR line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against both P fimbriated bacteria and oral bacteria.

Anti-oral-microbial adhesion fraction derived from vaccinium

Growing community of inventors

Givataim, Israel

Itzhak Ofek