Fujisawa Pharmaceutical Company, Ltd.

Itsuo Uchida

Masanobu Kohsaka

Hiroshi Imanaka

Kazuyoshi Umehara

Shigehiro Takase

Morita Iwami

Masanori Okamoto

Masashi Hashimoto

Michio Yamashita

Tadaaki Komori

Hiroshi Terano

Hirokazu Tanaka

Keizo Yoshida

Yoshio Kawai

Tsutomu Toyonaka Teraji

Kazuo Sakane

Masakuni Okuhara

Hiroshi Hatanaka

Seiji Hashimoto

Hiroyuki Setoi

Hidetsugu Murai

Kumiko Nitta

Junji Hosoda

Masanobu Konsaka

This invention relates to new carboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or aryl, and pharmaceutically acceptable salt thereof which inhibit activity of DHP-I, to a process for preparing them and to an antibacterial composition comprising them and carbapenem antibiotics.

Carboxylic acid derivatives

New nitro aliphatic compounds useful as antithrombotic and antihypertensing agents are disclosed.

Nitro aliphatic compounds, process for preparation thereof and use

The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl,

Method of treating tumors using tetracyclo compounds

The invention relates to novel furanone derivatives, having an aldose reductase-inhibitory activity, of the formula ##STR1## wherein A is a lower alkylene group,

Furanone derivatives, process for preparation thereof and use thereof

The invention relates to compounds of antihypertensive and antithrombotic activity of the formula or its pharmaceutically acceptable salt: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, or lower alkoxyphenyl,

Nitro aliphatic compounds and use thereof

New nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.

New Nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.

A biologically pure culture of Streptomyces sandaensis which is capable of producing an antitumor and antimicrobial compound, designated FR-900482 substance, is disclosed.

Biologically pure culture of Streptomyces sandaensis No. 6897

New tetracyclo compounds of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy or substituted iminomethyl,

Tetracyclo compounds and a pharmaceutical composition containing the same

N-acylpeptides are disclosed of the formula: ##STR1## wherein R.sup.1 is alkanoyloxy or alkenoyloxy; R.sup.2 is alkyl or alkenyl; R.sup.3 and R.sup.4 are each lower alkyl, hydroxy(lower)alkyl, ar(lower)alkyl, esterified carboxy(lower)alkyl, carboxy(lower)alkyl, protected amino(lower)alkyl or amino(lower)alkyl; R.sup.5 is hydrogen, hydroxy(lower)alkyl, protected amino(lower)alkyl, amino(lower)alkyl, carboxy(lower)alkyl or esterified carboxy(lower)alkyl; R.sup.6 is carboxy, esterified carboxy or sulfo(lower)alkyl; A.sup.1, A.sup.2 and A.sup.3 are each bond or lower alkylene; and m and n are each an integer of 0 or 1; or its pharmaceutically acceptable salt. These compounds have anti-complementary activity and fibrinolytic activity, and are useful as therapeutic agents for immune-complex diseases or autoimmune diseases such as nephritis, rheumatic diseases, systemic lupus erythematosus, etc. and thrombosis such as cerebral apoplexy, coronary insufficiency, pulmonary embolism, etc.

N-acyl peptide, processes for their preparation and pharmaceutical

Described are compounds of the formula: ##STR1## Wherein A is a lower alkylene group;

New furanone derivatives, process for preparation thereof and use thereof

This invention relates to tetrahydrofuran-carboxylic acid derivatives, of antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,

Tetrahydrofurnancarboxylic acid derivatives, processes for preparation

This invention relates to new N-acylpeptide compounds of immunological activity, said compounds being of the formula: ##EQU1## wherein R.sup.1 and R.sup.2 are each alkyl or alkenyl;

Growing community of inventors

Kyoto, Japan

Itsuo Uchida