Shionogi Company Limited

Teikoku Hormone Mfg. Co., Ltd.

Itsuo Makino

Kentaro Hirai

Teruyuki Ishiba

Shigeru Matsutani

Koichi Otani

Toshio Fujishita

Masami Doteuchi

Akira Kugimiya

Naohiro Onodera

Masami Doeteuchi

The present invention creates an azaindole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further providing a therapeutic agent for treating allergic diseases. A compound of the general formula (I) 

Azaindole derivative having PGD2 receptor antagonistic activity

An aminoalkylbenzene derivative of the formula: ##STR1## [wherein A is oxygen or sulfur;

Aminoalkylbenzene derivatives

Substituted aminoalkylbenzene type lower acylamides

4,1-Benzoxazepines of the following formula are novel central nervous system: ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.5 alkyl;

Triazolo-4,1-benzoxazepines having CNS activity

4,1-Benzoxazepines of the following formula are central nervous system drugs: ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.5 alkyl; X is hydrogen, halogen, or nitro; Y is phenyl, 2-halophenyl, 4-halophenyl, 2-trifluoromethylphenyl, or pyridyl; and ##STR2## is a group of the formula: ##STR3## (wherein Q is oxygen, sulfur, or hydrazono, with a proviso that, when Y is phenyl or 2-halophenyl and R is hydrogen, Q is neither oxygen nor sulfur;

4,1-Benzoxazepines and compositions

4,1-Benzoxazepines and thia analogs thereof of the formula: ##STR1## (wherein --A--B-- is the following group: ##STR2## (wherein R.sup.1 is hydrogen, C.sub.1 to C.sub.3 alkyl, or C.sub.7 to C.sub.9 aralkyl;

4,1-Benzoxazepines and thia analogs thereof

A compound of the formula: ##STR1## [wherein R is dimethylamino or 1-pyrrolidinyl;

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Kobe, Japan

Itsuo Makino