Bio-rad Laboratories, Inc.

Itay Barak

Boaz Ran

Evan Thrush

Yochanan Uri

Steve Swihart

Govind V Kaigala

Robert Dean Lovchik

Kevin McDonald

Steven Swihart

David P Taylor

Shai Nimri

Uri Issman

Igor Kochetkov

Shai Aharon

Marcel Buerge

The present disclosure is notably directed to a microfluidic probe head (), or MFP head, comprising a processing surface () having liquid injection and liquid aspiration apertures, as well as projections () extending from the processing surface (). The arrangement of injection and aspiration apertures provides for a hydrodynamic flow confinement within a processing region that is formed between the processing surface () and a substrate () or sample surface (for example, the bottom of a microtiter plate sample well ()), typically located beneath the processing surface (). The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.

Microfluidic probe head with aspiration posts

A combination imaging system includes a housing having a base and a lid, the lid having a closed position against the base and having an open position. The imaging device further includes a contact area image sensor. The lid shields the contact area image sensor from ambient light when the lid is in the closed position. The imaging device also includes a camera. The camera includes a lens, and the field of view of the camera encompasses at least a portion of an imaging area of the contact area image sensor when the lid is in the open position. The device may be especially useful for capturing a chemiluminescent image of an electrophoretic assay result, and capturing a colorimetric image of the same result, so that non-chemiluminescent protein standards may be located with respect to chemiluminescent analytes of interest.

Method of reading the result of an electrophoretic assay comprising a digital image indicating the intensity of light emitted by chemiluminescence from the output medium of the electrophoretic assay

Horizontal gel electrophoresis devices and methods of extracting a gel from a gel housing are provided. The devices allow for extraction of gels without having to open the housing comprising the gel. The devices include gel cassettes that simplify the automation of gel electrophoresis and electroblotting of proteins. Also provided are devices that allow for horizontal gel electrophoresis without the need to from a liquid seal between the buffer reservoir and the gel housing. Also described are methods for extracting a gel from a housing without opening the housing.

Horizontal electrophoresis separation device without seal and method of extracting gel without opening cassette

In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.

Digital imaging with masked pixels

Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.

Contact imaging devices for fluorescence applications

Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.

Contact imager

A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising:

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Kibuts Yasur, Israel

Itay Barak