Sumitomo Dainippon Pharma Co., Ltd.

Dainippon Sumitomo Pharma Co., Ltd.

Itaru Natsutani

Hidefumi Yoshinaga

Yoko Takahashi

Tomohiro Toyoda

Izumi Sasaki

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HTantagonistic action (antidepressive and anxiolytic effects), in particular, 5-HTinverse agonistic action comprising Compound (1): 

Pyrazole compound

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HTantagonistic action (antidepressive and anxiolytic effects), in particular, 5-HTinverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HTantagonistic action (antidepressive and anxiolytic effects), in particular, 5-HTinverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereofwherein R, R, Rand Rare independently hydrogen or Calkyl etc.; Ris Calkyl or &#x2014;(CRR)-E; R, R, Rand Rare independently hydrogen, fluorine or Calkyl; A is Caryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is Ccycloalkyl or Caryl etc.; L is oxygen, sulfur or &#x2014;NR&#x2014;; n is 1, 2 or 3; Ris hydrogen or Calkyl etc.; and X is hydrogen or halogen etc.

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Suita, Japan

Itaru Natsutani