Japan Science and Technology Agency

Canon Kabushiki Kaisha

Kyoto University

Dojindo Laboratories

Fukuoka Prefectural Government

Itaru Hamachi

Tetsuya Yano

Takashi Sakamoto

Kimihiro Yoshimura

Fumio Yamauchi

Shoji Takeuchi

Kazumi Sasamoto

Munetaka Ishiyama

Hiroaki Onoe

Daisuke Kiriya

Masaaki Inoue

Tomoyuki Ishikawa

Rieko Kuroda

Satoko Yamashita

Takeshi Ido

Chizu Ikeda

Takahiro Nagata

Tetsuyuki Akao

Kenichi Kusumoto

Masato Ikeda

A method for preparing a linearly extended supramolecular fiber or a plurality of linearly aligned supramolecular fibers, which comprises the step of allowing supramolecular monomers to be self-assembled in a microfluidic channel.

Process for producing supramolecular fiber

The present invention provides a carrier capable of highly efficiently introducing a compound into cells with low cytotoxicity, which contains peptide lipids represented by the following formula, and a method for introducing a compound into cells using the carrier: wherein Ris an amino acid or peptide having 1-10 amino acid residues, Ris a side chain of any amino acid, provided that Rhas a carboxyl group, the carboxyl group may be an ester with a hydrocarbon group having 1-30 carbon atoms, Ris a hydrocarbon group having 1-30 carbon atoms. 

Peptide lipid-containing carrier and method for introducing compound into cells using same

A compound which captures a multisite phosphorylated peptide or protein specifically to a phosphorylation site and a method for detecting the peptide or protein using the compound. Particularly, a compound which specifically detects an excessively phosphorylated tau protein observed in the brain affected by Alzheimer's disease and a method for diagnosing Alzheimer's disease in vitro or in vivo using the compound are provided. By bringing a metal complex compound having two dipicolylamine (Dpa) moieties and a spacer including a chromogenic or luminescent functional or atom group into contact with a multisite phosphorylated peptide or protein, the compound recognizes the distance between phosphate groups and specifically binds to the peptide or protein, and a multisite phosphorylated peptide or protein or kinase activity is optically detected by measuring the change, or a multisite phosphorylated peptide or protein or kinase activity is imaged by an optical imaging method applying the change in luminescence.

Multisite phosphorylated peptide (protein) recognizing compound and detection method, imaging method, alzheimer's disease diagnosing method and reagent kit using the same

Disclosed is a fluorescent sensor for phosphate ion and phosphorylated peptide, which comprises a phosphate anion-selective fluorescent compound expressed by the following general formula (1). In the formula (1), FL represents a fluorescent functional group or atomic group having an aromatic ring or heterocyclic ring (for example, dimethylanthlyl group), and X represents a functional group or atomic group which will be liberated in an aqueous solution to form an anion (for example, NO): 

Fluorescent sensor for phosphate ion and phosphorylated peptide

Growing community of inventors

Kyoto, Japan

Itaru Hamachi