Eisai R&d Management Co., Ltd.

Eisai Company, Limited

Itaru Arimoto

Koichi Ito

Satoshi Nagato

Tomohiro Matsushima

Takao Omae

Katsutoshi Nishiura

Yukiko Sugaya

Yoshio Urawa

Akio Kayano

Hiroyuki Naka

Yasuyuki Suzuki

Tatsuo Watanabe

Yasuhiro Funahashi

Akihiko Tsuruoka

Masayuki Matsukura

Keiko Takahashi

Kazuki Miyazaki

Yuji Yamamoto

Hiroshi Obaishi

Atsushi Kamada

Toru Haneda

Junji Matsui

Junichi Kamata

Yoshio Fukuda

Kazuhiro Yoshizawa

Taiju Nakamura

Takahisa Sakaguchi

Yusuke Ayata

Atsumi Yamaguchi

Masaharu Gotoda

Katsuji Nakamura

Fusayo Mimura

Takako Yoshiba

Ken-ichi Nomoto

Sachi Suzuki

Naoko Suzuki

Kenji Matsui

Ken-Ichi Nomoto

The present inventions provide a method for commercially producing a 1,2 -dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2 -dihydropyridin-2-one and production processes therefore.

Method for producing 1,2-dihydropyridine-2-one compound

The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one and production processes therefore.

Method for producing 1, 2-dihydropyridine-2-one compound

A crystal of a 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide hydrochloride, hydrobromide, p-toluenesulfonate, sulfate, methanesulfonate or ethanesulfonate, or a solvate thereof.

Crystalline form of the salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide or the solvate of the salt and a process for preparing the same

Compounds represented by the following general formula: [wherein Ais an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xis &#x2014;O&#x2014;, &#x2014;S&#x2014;, etc.; Yis an optionally substituted Caryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tis a group represented by the following general formula: (wherein Eis a single bond or &#x2014;N(R)&#x2014;, Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, etc. and Zrepresents a Calkyl group, a Calicyclic hydrocarbon group, a Caryl group, etc.)],

Nitrogen-containing aromatic derivatives

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Tokyo, Japan

Itaru Arimoto