Roussel Uclaf

Italo Medici

Andre Farcilli

Robert Fournex

Julien Warnant

Francois Clemence

Fernando Barzaghi

Edmond Toromanoff

Colette Tournemine

Novel 20,21-dinoreburnamenines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and .dbd.CH.sub.2, the wavy line connecting to the E ring being a single bond when R is hydrogen or alkyl of 1 to 4 carbon atoms or a double bond when R is .dbd.CH.sub.2 and the dotted line being possibly an endo carbon-carbon bond when R is hydrogen or alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts in all their possible isomers forms, racemic mixtures and optical isomers having oxygenating and cerebral vasoregulating activity of great value and a novel process and intermediates for their preparation.

Blood oxygenating and cerebral vasoregulating 20,21-dinoreburnamenines

New 20,21-dinoreburnamenine derivatives are disclosed which have the formula I ##STR1## wherein the hydroxyl in the 14-position of the molecule is in either of the two possible positions at the carbon atom in the 14-position to which the isomers A and B correspond and the hydrogens in the 3-position and the 16-position of the molecule are in cis- or in trans-position to each other, and their pharmaceutically acceptable acid addition salts, as well as pharmaceutical formulations thereof. The new compounds of formula I are prepared by reducing the corresponding 14-oxoderivatives. They are effective in favorably influencing the cerebral vascular circulation.

Cerebral vasodilating 20,21-dinoreburnamenine derivatives

Novel eburnamenine derivatives of the formula ##STR1## in the form of racemic mixtures or optically active isomers and their non-toxic, pharmaceutically acceptable acid addition salts which are oxygenators and cerebral vasoregulators of great value.

14-Imino-(15H)-eburnamine compounds, compositions, methods of use and

Process for the preparation of glaziovine by treating N-methyl bromococlaurine in an inert organic solvent with a tin hydride tri-substituted with organic radicals in the presence of a free radical promoter.

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Bondy, France

Italo Medici