Olix Pharmaceuticals, Inc.

Isu Hong

Sun Woo Hong

Ji Hyun Kim

Jihye Hwang

Dong-Ki Lee

Dong Ki Lee

Sun Hong

Ji Hye Hwang

In certain aspects, provided herein are RNA complexes that inhibit Myeloid differentiation primary response gene 88 (MyD88) and/or Toll-like receptor 3 (TLR3) and are useful in the treatment of age-related macular degeneration (AMD). In certain aspects, provided herein are pharmaceutical compositions comprising such RNA complexes and methods of using such RNA complexes and pharmaceutical compositions.

Treatment of age-related macular degeneration using RNA complexes that target MyD88 or TLR3

In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs and lasiRNAs) that inhibit tyrosinase expression and are therefore useful for reducing melanin production and for treating pigmentation-related disorders associated with excessive melanin production, such as melasma and age spots.

RNA complexes that inhibit melanin production

Treatment of age-related macular degeneration using RNA complexes that target MYD88 or TLR3

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Seoul, South Korea

Isu Hong