Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

István Lászlofi

Irén Hortobágyi

Zsuzsanna Kardos

Gábor Havasi

László Takács

Péter Buzder-Lantos

Zoltán Bischof

Ádám Bódis

Tibor Kiss

Ervin Vajda

The subject of the invention is a process for the preparation of high purity prostaglandin acid of the general formula II wherein the bonds marked with dotted lines represent single or double bonds wherein the double bonds may be cis- or trans oriented, Y represents O or CH, and Rstands for a phenyl group which is optionally substituted with CF, wherein the crude prostaglandin acid of the general formula II is purified by normal phase silicagel chromatography. 

Pocess for the preparation of high purity prostaglandins

The invention relates to a process for the preparation of travoprost of formula (I), comprising that, the compound of formula (II), is stereoselectively reduced, the resulting compound of formula (III), is if desired crystallized, the lactone group of the compound of formula (III) is reduced, the p-phenyl-benzoyl protecting group of the thus obtained compound of formula (IV), is removed, the resulting triol of formula (V), is, if desired after crystallization, transformed by Wittig reaction into the acid of formula (VI), which is then esterified. 

Process for the preparation of travoprost

Growing community of inventors

Budapest, Hungary

István Lászlofi