Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Chinoin Gyogyszer Rt

Istvan Turcsan

Eva Somfai

Istvan Jelinek

Gyorgy Lugosi

Laszlo Simandi

Janos Bodnar

Sandor Virag

Jozsef Szejtli

Antal Simay

Dezso Korbonits

Pal Kiss

Agnes Stadler Nee Szoke

Maria Vikmon Nee Kiraly

Istvan Csik

Iren Csaszar Nee Toth

Antal S May

Process for the preparation of an inclusion complex of

The invention relates to a process for the preparation of carbamic acid phenyl esters of the formula (I) ##STR1## by acylating phenol derivatives of the formula (II) ##STR2## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, aralkyl having 7 to 16 carbon atoms which groups can be substituted by one or more alkyl groups,

Process for O-acylating phenol derivatives and acylating compositions

A process is disclosed for preparing a carbamic acid phenyl ester of the formula (I) ##STR1## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, or aralkyl having 7 to 16 carbon atoms, wherein the aryl, cycloalkyl or aralkyl is unsubstituted or substituted by at least one alkyl group having 1 to 8 carbon atoms;

In the production of perparine or papaverine and their hydrochlorides, the formation of impurities in the reaction mixture is suppressed by fractionating a 3,4-di-R-benzyl-cyanide in the presence of an organic base (e.g. pyridine, dimethylformamide, ethylenediamine or triethylamine) followed by hydrogenation with a Raney-nickel catalyst treated with aqueous ammonium carbonate solution. R is methoxy or ethoxy.

Process for the manufacture of pure isoquinoline derivatives

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Budapest, Hungary

Istvan Turcsan