Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Istvan Tomoskozi

Gabor Kovacs

Istvan Stadler

Istvan Szekely

Csaba Szantay

Vilmos Simonidesz

Marianna Lovasz Nee Gaspar

Peter Gyory

Sandor Virag

Peter S Kormoczy

Karoly Kanai

Geza Galambos

Gyorgy Dorman

Zsuzsa Visky Nee Gombos

Julia Remport Nee Radoczi

Gyula Papp

Laszlo Szekeres

Jeno Marton

Jozsef Ivanics

Pal Hadhazy

Karoly Kanay

Julia Nee Remport

Zsuzsa Nee Visky

Borbala Nee Keresztes

Borbala Keresztesnee Ordog

Peter Gyori

Peter Kormoczky

Marianna Kovacs

Borbala Keresztes Nee Ordog

Eva Udvary

The invention relates to new 7-oxo-PGI.sub.2 -ephedrine salt analogues of the Formula I ##STR1## wherein A stands for --(CH.sub.2).sub.2 --, cis or trans --CH.dbd.CH-- or --C.tbd.C--;

7-oxo-PGI.sub.2 -ephedrine salts and their pharmaceutical compositions

Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation, R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or --C.dbd.C--, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

Selective biologically active 7-oxo-prostacyclin derivatives and

The present invention relates to a process for the preparation of compounds of the general Formula I ##STR1## (wherein A is a straight or branched chain alkylene group having 1-5 carbon atoms;

Preparation of 6-keto-7-oxo-PGF.sub.1.alpha. -derivatives

A compound having vasodilative, bronchodilative, stomach-mucosa-protective and platelet-aggregation-inhibiting activity has the formula A 4-thia- or 4-sulfinyl-PGI.sub.1 -compound of the formula I ##STR1## wherein Q stands for --S-- or --SO--,

Vasodilative 4-thia-PGI.sub.1 and 4-sulfinyl-PGI.sub.1 and derivatives

A process for the preparation of optically active or racemic lactone diol derivatives of the formula ##STR1## (for use as intermediates in the Corey prostaglandin synthesis). Optically active or racemic lactone diol derivatives are inclosed, in which

Process for making bicyclic lactone derivatives for use as intermediates

A process for the preparation of bicyclic enon compounds in which a lactone diol is selectively oxidized to obtain a hydroxy-aldehyde with one hydroxyl group and, without isolation, the hydroxy-aldehyde is reacted with a phosphorus compound. The reaction product can be acylated or silylated.

Process for the preparation of bicyclic enone compounds

A compound of the formula is disclosed. ##STR1## wherein R.sup.3 and R.sup.4 are the same or different and are each hydrogen, lower alkanoyl, lower alkanoyl substituted by 1, 2, or 3 halogen atoms, or R.sup.3 and R.sup.4 together form an ##STR2## group in which R.sup.5 and R.sup.6 are the same or different and are each hydrogen, alkyl or aryl as well as a process for the preparation thereof.

Bicyclic lactone derivatives employed as intermediates in the synthesis

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Budapest, Hungary

Istvan Tomoskozi