Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Sugen Incorporated

University of California

Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Bio-Signal Corporation Ltd.

Other

Chinoin Pharmaceutical and Chemical Works Private Company Ltd.

Chinoin Gyogyszer Es Vegyeszeti

Agro-Chemie

Agro-Chemie Novenyvedoszer Gyarto Ertekesito Est Forgalmazo Kft.

Istvan Szekely

Lajos T Nagy

Laszlo Pap

Bela Bertok

Sandor Botar

Gabor Kovacs

Eva Somfai

Andras Szego

Rudolf Soos

Sandor Zoltan

Gyorgy Hidasi

Agnes Hegedus

Antal Gajary

Marianna Lovasz Nee Gaspar

Axel Ullrich

Csaba Szantay

Klaus Peter Hirth

Istvan Stadler

Tamas Szabolcsi

Reiner Lammers

Janis Haimichael

Aviv Gazit

Laura Kay Shawver

Alex Levitzki

Elaina Mann

Vilmos Simonidesz

Istvan Tomoskozi

Tamas Bajor

Antal Gajari

Erzsebet Radvany

Andrea Toth

Peng Cho Tang

Peter S Kormoczy

Donna Pruess Schwartz

Karoly Horvath

Geza Arvai

Janis Hajimichael

Gyorgi Keri

Krisztina Kekesi

Dennis J Slamon

Kalman Takacs

Katalin Marmarosi

Lajos Novak

Bela Koszegi

Pal Hadhazy

Zsuzsanna Kuruczne Ribai

Angelika Thurna

Gyorgy Szucsany

Edit Bleicher

Laszlo Poppe

Fairooz F Kabbinavar

Julia Remport Nee Radoczi

Zsuzsa Visky Nee Gombos

Sandor Virag

Katalin Marmarosi Nee Kellner

Peter Bohus

Jozsef Ivanics

Karoly Kanai

Laszlo Fesus

Jozsef Rakoczi

Erzsebet Szalay

Jozsef Nemes

Matyas Szentivanyi

Peter Sarkozy

Jeno Kiraly

Janos Ori

Peter Sarkozi

Zoltan Karadi

Tamasne Marmarosi

Miklos Szelestei

Laszlo Vidra

Janos Ri

Gyula Balogh

Judit Skopal

Laura K Shawyer

Ildiko Bakonyvari

Iren Czudor

Zsuzsa R Kuruczne

Laszlo Csiz

Ruldof Soos

Aniko Deak Nee Moinar

Aniko Deak

Janos Grosch

Istvan Schler

Sandor Bota

Viktoria Kollarik Nee Hasek

Laszio Pap

Aniko D Molnar

Katalin Marmarosi N Ee Kellner

Janosne Hadobas

B Iidiko Menesine

Borbala Keresztes Nee Ordog

Julia Nee Remport

Zsuzsa Nee Visky

Borbala Nee Keresztes

Borbala Keresztesnee Ordog

Marianne Lovasz Nee Gaspar

Joszef Dukai

Marianna Lovasz, Nee Gaspar

Mariann Lovasz Nee Gaspar

The subject of our invention is the process for the preparation of the 1-(3,4-dimethoxyphenyl)ethanol of formula (I), by the reduction of 3,4-dimethoxyacetophenone of formula (II), characterized in that the carbonyl group of the 3,4-dimethoxyacetophenone of formula (II) is reduced by 1 mol of hydrogen under the conditions of catalytic hydrogenation.

Process for the preparation of 1-(3,4-dimethoxyphenyl)ethanol

The present invention concerns compounds which can inhibit platelet derived growth factor receptor (PDGF-R) activity, preferably such compounds also inhibit the activity other members of the PDGF-R super family and are selective for members of the PDGF-R super family. The PDGF-R super family includes PDGF-R and PDGF-R related kinases Flt, and KDR. The featured compounds are active on cell cultures to reduce the activity of the PDGF-R and preferably one or more PDGF-R related kinases. An example of a featured compound, A10 (see FIG.,), and its ability to inhibit growth of tumor cells in vivo is described below. Using the present application as guide other compounds able to inhibit PDGF-R and preferably Flt and/or KDR can be obtained. Such compounds are preferably used to treat patients suffering from cell proliferative disorders characterized by inappropriate PDGF-R activity.

Treatment of platelet derived growth factor related disorders such as cancers

Process for the preparation of benzyl-ethers

Pesticide compounds, compositions and process for the preparation thereof

The present invention concerns compounds which can inhibit platelet derived growth factor receptor (PDGF-R) activity, preferably such compounds also inhibit the activity other members of the PDGF-R super family and are selective for members of the PDGF-R super family. The PDGF-R super family includes PDGF-R and PDGF-R related kinases Flt, and KDR. The featured compounds are active on cell cultures to reduce the activity of the PDGF-R and preferably one or more PDGF-R related kinases. An example of a featured compound, A10 (see FIG. 1a), and its ability to inhibit growth of tumor cells in vivo is described below. Using the present application as guide other compounds able to inhibit PDGF-R and preferably Flt and/or KDR can be obtained. Such compounds are preferably used to treat patients suffering from cell proliferative disorders characterized by inappropriate PDGF-R activity.

Treatment of platelet derived growth factor related disorders such as

Pesticide formulations and process for the manufacture thereof

Method for treating a patient inflicted with a cell proliferation disorder, such as a cancer, characterized by inappropriate PDGF-R activity. The method involves the step of administering to the patient a therapeutically effective amount of a composition described in application.

The invention relates to novel 1,2-dihydro-1,2,4,5-tetrazine derivatives of the formula (IV) ##STR1## wherein means fluorine, chlorine or bromine; and

Acaricidally active tetrazine derivatives

The invention relates to novel tetrazine derivatives of the formula (I), ##STR1## wherein X is fluorine, chlorine or bromine; and

The invention relates to novel combined compositions for combatting plant, animal and sanitarian as well as forestry, horticultural and warehouse pests. These compositions contain a pyrethroid-type insecticide as an insecticidally active ingredient and at least one fungicide inhibiting the ergosterol biosynthesis as activity-strengthening agent as well as optionally piperonylbutoxide and other additives. The advantages of the compositions according to the invention consist therein that the activity-strengthening substances used are fungicidal agents widely used and have an advantageous toxicology. The activity-strengthening agent exerts a synergistic effect together with the pyrethroid-type insecticide. The combinations according to the invention bear an outstanding importance in the protection of stored crops.

Combined compositions

A pure crystalline O-(2-hydroxy-3-piperidino-1-propyl) nicotinic acid amidoxime base of the Formula (Ib) ##STR1## is disclosed characterized by a melting point of 70.degree. to 73.degree. C., giving, when dissolved in an amount of 1 to 10 ml of concentrated sulfuric acid, a yellow homogeneous solution, and showing the following spectral characteristics:

Highly pure amidoximes

Pesticidal compositions comprising ethoxylated citric or tartaric acid

Growing community of inventors

Dunakeszi, Hungary

Istvan Szekely