Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Istvan Stadler

Gabor Kovacs

Vilmos Simonidesz

Istvan Tomoskozi

Istvan Szekely

Peter S Kormoczy

Csaba Szantay

Sandor Virag

Jozsef Ivanics

Geza Galambos

Marianna Lovasz Nee Gaspar

Peter Gyory

Pal Hadhazy

Gyorgy Dorman

Antal Simay

Tibor Szabo

Gyula Sebestyen

Kalman Takacs

Laszlo Institoris

Karoly Horvath

Bela Koszegi

Ilona K Ajzert

Krisztina Kekesi

Marian E Puskas

Maria H Papp

Zoltan Sumeghy

Karoly Kanay

Julia Remport Nee Radoczi

Zsuzsa Visky Nee Gombos

Jozsef Szejtli

Sandor Botar

Gyorgy Cseh

Gyula Papp

Laszlo Szekeres

Lajos Novak

Jeno Marton

Gyula Dalmadi

Istvan Pallagi

Peter L Nagy

Karoly Kanai

Peter Literati Nagy

Agnes Papp Nee Behr

Peter Kormoczi

Judit Skopal

Julia Nee Remport

Zsuzsa Nee Visky

Borbala Nee Keresztes

Borbala Keresztesnee Ordog

Julia Der Nee Foldvary

Mariann Lovasz Nee Gaspar

Istvan Rakoczi

Laszlo Muszbek

Gaza Galambos

Jozsef Aszodi

Magdolna Szejtli Nee Rengei

Peter Kormoczky

Marianna Kovacs

Istvan Tomoskozy

Borbala Keresztes Nee Ordog

Miklos Kiss

Eva Udvary

The invention relates to novel interfuranylene-prostacyclin derivatives of the general formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or a straight or branched chain C.sub.1-6 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group;

Interfuranylene prostacyclins

The invention relates to new 7-oxo-PGI.sub.2 -ephedrine salt analogues of the Formula I ##STR1## wherein A stands for --(CH.sub.2).sub.2 --, cis or trans --CH.dbd.CH-- or --C.tbd.C--;

7-oxo-PGI.sub.2 -ephedrine salts and their pharmaceutical compositions

A new method is disclosed for the treatment and prevention of gastrointestinal ulcers or erosions which comprises the administration of a pharmaceutically effective amount of a PGI.sub.2 methyl ester-beta cyclodextrin complex to a patient in need of said treatment wherein the amount of the PGI.sub.2 methyl ester constitutes 1 to 15% by weight of the complex.

Method of treating ulcers and erosions in the gastrointestinal system

Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation, R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or --C.dbd.C--, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

Selective biologically active 7-oxo-prostacyclin derivatives and

2,3,4-trinor-1,5-inter-m-phenylene-prostacycline derivatives of the formula (I), ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1-4 alkyl group, an alkali metal cation or a primary, secondary, tertiary or quaternary ammonium cation,

2,3,4-Trinor-m-inter-phenylene-prostaglandin derivatives and

The invention relates to a process for the preparation of novel 4-oxo-PGI.sub.2 derivatives of formula I ##STR1## where (a) compounds of formula III ##STR2## are oxidized, then the obtained 5-substituted-4-oxo-PGI.sub.1 derivatives of general formula II ##STR3## are eliminated by the splitting off of the W-H-molecule, or (b) the compounds of formula IV ##STR4## are reacted in a solvent in the presence of a catalyst with compounds of general formula V ##STR5## then the obtained compounds of formula I are transformed if desired by saponification, hydrolysis, salt formation, insertion of a protection group to another compound which belongs to the compounds of formula I, too. The pharmaceutical products of the invention can be used for the treatment of circulatory diseases, they inhibit the aggregation of blood plaques, dilate the bronchi and inhibit the secretion of gastric acid.

4-Oxo-PGI.sub.2 compounds, their use in inhibition of thrombii and their

The invention relates to new optically active or racemic 13-thia-prostacycline derivatives of the Formula I ##STR1## wherein R.sup.1 is hydrogen, a pharmaceutically acceptable cation or a straight or branched chain alkyl group having 1-5 carbon atoms;

13-Thia-prostacycline derivatives

The invention concerns new sulfur-containing isoquinoline derivatives. More particularly, the invention relates to isoquinoline derivatives of the general formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms,

Sulfur-containing isoquinoline derivatives in pharmaceutical

A compound having vasodilative, bronchodilative, stomach-mucosa-protective and platelet-aggregation-inhibiting activity has the formula A 4-thia- or 4-sulfinyl-PGI.sub.1 -compound of the formula I ##STR1## wherein Q stands for --S-- or --SO--,

Vasodilative 4-thia-PGI.sub.1 and 4-sulfinyl-PGI.sub.1 and derivatives

Isoquinolines are disclosed of the formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms,

Sulfur-containing isoquinoline derivatives, process for the preparation

New PGI.sub.2 derivatives and a process for their preparation are disclosed of the formula (I) ##STR1## wherein Q is hydrogen, a pharmacologically acceptable cation, or lower alkyl;

7-Oxo-PGI.sub.2 -derivatives and process for the preparation thereof and

New compounds and a process for making the same, for use in inhibiting aggregation in human blood and inhibiting the growth of tumors, said compounds being of the general formula: ##STR1## wherein R is hydrogen, alkanoyl, substituted alkanoyl, aralkanoyl or aroyl and  represents .alpha. or .beta. steric position or .alpha. and .beta. position, with the provision that if R stands for p-phenyl-benzoyl then methoxy in the position 2 may stand only in .alpha. or only in .beta. steric position.

Method for inhibiting aggregation of human thrombocytes

Racemic or optically active compounds with antitumor activity of the formula: ##STR1## wherein X is oxygen or sulfur;

Derivatives of bicyclic lactols

A process for the preparation of optically active or racemic lactone diol derivatives of the formula ##STR1## (for use as intermediates in the Corey prostaglandin synthesis). Optically active or racemic lactone diol derivatives are inclosed, in which

Process for making bicyclic lactone derivatives for use as intermediates

A process for the preparation of bicyclic enon compounds in which a lactone diol is selectively oxidized to obtain a hydroxy-aldehyde with one hydroxyl group and, without isolation, the hydroxy-aldehyde is reacted with a phosphorus compound. The reaction product can be acylated or silylated.

Process for the preparation of bicyclic enone compounds

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Budapest, Hungary

Istvan Stadler