Egis Gyogyszergyar

Basf Aktiengesellschaft

Egis Cyogyszergvar

Istvan Simonyi

Frigyes Gorgenyi

Marton Fekete

Attila Mandi

Ivan Beck

Lujza E Petocz

Pal Benko

Gabor Gigler

Gyula Sebestyen

Kalman Nagy

Daniel Bozsing

Janos Egri

Peter Tompe

Pal Vago

Laszlo Levai

Andras Dietz

Marta Kovacs

Janos Imre

Eva Furdyga

Elemer Jakfalvi

Katalin Zukovics Nee Sumeg

Eva J Tajthy Nee Juhasz

Istvan Seres

Maria Szeli

Gyorgyi Kovanyi Nee Lax

Gyorgy Mikite

Gyorgyi Zalavari Nee Dosa

Eva Poczik

Ilona Dinnyes Nee Nagy

Erzsebet Kiss Nee Bertok

Karoly Magyar

Eniko Szirt Nee Kiszelly

Pal Fekete

Ferenc Simon

Eniko Kiszelly

Laszlo Puskas

Attila Nagy

Lajos Fekete

Klara Gado

Maria Hegedus

Gizella Miholics

Katalin Sumeg Nee Zukovics

Gizelle Miholics

Egri Janos

The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, then R stands for a group of the Formula (a) ##STR3## and if n is 3, then R represents hydrogen) with methyl acetoacetate of the Formula III

1,4,Dihydro-pyridine intermediates

The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarbox ylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene methanediamine with methyl acetoacetate in the presence of an amine compound or by reacting the monomeric or trimeric from of 2-nitrobenzaldimine with methyl acetoacetate.

Process for the preparation of 1,4-dihydro-pyridine derivatives

The invention relates to weight gain-increasing compositions, particularly fodder supplement, premix, drinking water supplement, bolus and/or microcapsule containing 0.001 to 90% by weight of 1-(3,5-dihydroxyphenyl)-2-(tertiary butylamino)-ethanol or a physiologically acceptable acid addition salt thereof as active ingredient in admixture with inert solid and/or liquid carrier(s).

Method for weight gain-increasing of fodder utilization of pigs, cattle

The compounds of the general Formula I ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different and each stands for hydrogen, hydroxy, C.sub.1-6 alkoxy, C.sub.1-6 alkoxy-C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy or phenyl-(C.sub.1-3 alkoxy), or R.sup.1 and R.sup.2 together form C.sub.1-2 alkylenedioxy; with the proviso that at least one of symbols R.sup.1 and R.sup.2 is other than hydrogen and with the further proviso that R.sup.1 and R.sup.2 can not represent 3,4-dimethoxy substitution) and their pharmaceutically acceptable acid addition salts exhibit useful analgesic, antipyretic, anti-inflammatory, anti-anginal and antioxidant effect.

Pharmaceutical compositions

The invention relates to pharmaceutical compositions having analgesic and/or anti-inflammatory effect comprising as active ingredient 2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine or a pharmaceutically acceptable acid addition salt thereof.

Pharmaceutical composition

The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxyquinoline of formula (I) ##STR1## and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails. The complex of formula (I) is prepared by reacting a solution of an alkali metal salt of 5-chloro-7-iodo-8-hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.

Pharmaceutical composition comprising an organic zinc complex and a

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Budapest, Hungary

Istvan Simonyi