Richter Gedeon Vegyeszeti Gyar Rt

Istvan Schon

Laszlo Szporny

Gyorgy Hajos

Lajos Kisfaludy

Laszlo Denes

Tamas Szirtes

Lajos Kisfaludy, Deceased

Bela Szende

Olga Nyeki Nee Kuprina

Olga Nyeki

Laszlo Varga

Vince Varro

Jozsef Nafradi

Elemer Ezer

Sandor Bajusz

Judit Matuz

Katalin Saghy

Gyorgy Domany

Istvan Teplan

Lajos Kovacs

Janos Seprodi

Maria Gazdag

Zsolt Vadasz

Attila Juhasz

Karoly Lapis

Miklos Low

Imre Peter

Andras Balazs

Judit Erchegyi

Bela Kanyicska

Laszlo Graf

Kalman Medzihradszky

Geza Ivanyi

Olga N Nee Kuprina

Iidiko Berhardt

Gizella Lorant

Zsuzsanna Muck

Rosa Beks

Maria Sz Sarkozi

Andrae Turan

Julia Ember

Marta Renyei

Andras Selmezci

Kuprina O Nyeki

Tamas Berhardt

The present invention relates to novel peptides of formulae

Pharmaceutical compositions comprising novel oligopeptides exhibiting

The present invention relates to a process for the preparation of high purity crystalline peptides Arg Lys Asp hydrate acetate and Arg Lys Asp Val from crude, amorphous peptides Arg Lys Asp and Arg Lys Asp Val hydrate acetate. The process is characterized in that

High purity crystalline peptides arglysasp and arglysaspval and a

The invention relates to novel pyridine derivatives of formula (I), ##STR1## wherein Q stand for a nitro or cyano group; and

Pyridine derivatives and pharmaceutical compositions containing them

Peptides are disclosed which inhibit the immune system. The peptides are selected from the group consisting of:

Novel peptides inhibiting the maturation of t-lymphocytes and the

Antileukemic and immunostimulant peptides

The invention relates to novel peptides and their acid addition salts, suppressing the function of the immune system, pharmaceutical compositions containing these peptides as well as to a process for preparing these peptides and compositions. The peptides are represented by formulae (1) to (16): ##STR1## The novel peptides are useful for the therapy of diseases where a decrease in the activity of the immune system is desirable.

Novel peptides suppressing the function of the immune system,

The present invention relates to novel gonadoliberine analogues of formula I

Gonadoliberine analogues of high activity

Peptides affecting the immune regulation selected from the following group:

Peptides affecting the immune regulation and a process for their

The invention relates to novel peptides of formula (I),

Phenylglycine-containing new peptides with gastrine effects and a

.alpha.-AMINOACYL CONTAINING NEW PEPTIDES WITH GASTRIN EFFECTS AND A

The invention relates to the preparation of biologically active polypeptides containing the aspartyl group, particularly an aspartyl-glycine moiety, using the active-ester technique. According to the method of the invention, human adrenocorticotropic hormone and its fragments characteristic to the individual species, as well as the blocked derivatives of such compounds are prepared by the pentafluorophenol method, i.e., the carboxy group of the acylating component is activated by converting it into pentafluorophenyl ester in the coupling reaction carried out with blocked peptides containing the aspartyl group or an aspartylglycine moiety. The acylation is carried out preferably using equimolar quantities of the respective reactants. The free peptides obtained after removing the blocking groups can be converted into their acid addition salts or pharmaceutically acceptable complexes or condensates. Human adrenocorticotropic hormone and its derivatives are valuable substances of therapeutical activity.

Process for the preparation of biologically active polypeptides

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Budapest, Hungary

Istvan Schon