Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

Biogal Gyogyszerarugyar Rt

Istvan Melczer

Vilmos Keri

Adrienne Kovacsne-Mezei

Janos Balint

Gyorgy Deak

Anita Karczub

Berta Mako

Ferenc Radnai

Tibor Szanya

Erno Karacxony

Csaba Hajdufi

Laszlo Hanak

Judit Dencs

Gyongyi Strbka

Gyula Marton

Edit Nagy

Janos Kelemen

The present invention provides processes for crystallization of macrolides, specifically pimecrolimus and tacrolimus.

Processes for producing crystalline macrolides

The present invention provides pure pravastatin compositions and pure compactin compositions, and methods for the preparation thereof.

Method of purifying pravastatin

A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80.degree. C. to about 115.degree. C., melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol.

Process for the purification of cyclosporin A

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Debrecen, Hungary

Istvan Melczer