Schering Aktiengesellschaft

Egis Gyogyszergyar Rt.

Egis Gyogyszergyar Zrt.

Egis Gyogyszergyar

Istvan Ling

Tamas Hamori

Ferenc Andrasi

Pal Berzsenyi

Istvan Tarnawa

Sandor Solyom

Marta Szollosy

Gyula Simig

Imre Moravcsik

Antal Simay

Gabor Gigler

Jozsef Barkoczy

Balazs Volk

Gabor Zolyomi

Melinda Gal

Andras Dancso

Gizella Abraham

Istvan Gacsalyi

Istvan Elekes

Gabor Nemeth

Sandor Elek

Jeno Korosi

Tibor Lang

Peter Botka

Gyorgy Rabloczky

Andras Varro

Istvan Pallagi

Maria Kuhar Nee Kurthy

Eszter Szentkuti

Katalin Eszter Horvath

Gyorgyi Kovanyine Lax

Eva Szabo

Katalin Horvath

Emese Csuzdi

Zsuzsanna Lang Nee Rihmer

Geza Szabo

Ferenc Antoni

Tibor Hasko

Janos Petho

Ernese Csuzdi

Szabolcs Kertesz

Laszlo Gabor Harsing

Erzsebet Birkas

Gabor Kapus

Emese Csuzdl

Franciska Erdo

Agnes Kenez

Ferenc Bertha

Judit Sarossy Nee Kincsessy

Balazs Mihalik

Agnes Angyalne Pataki

Gabor Laszlo Kapus

Adrienn Palvolgyi

Lax Gyorgyi Kovanyine

Gyorgy Jeges

Peter Gregor

Jeno Peter Seres

Gyula Szücs

Compounds of formula (I) having a selective dual action on the central GABAergic system, and a process for their preparation and to pharmaceutical compositions containing them.

Dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them

The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula  Still more particularly the invention relates to the preparation of high purity vortioxetine L-(+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.

Process for the preparation of vortioxetine salts

The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula &#x2014;NH&#x2014;R', wherein R&#x2032; stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity. 

8-chloro-2,3-benzodiazepine derivatives

Compounds of formula I are described, their production and use in pharmaceutical agents.

Condensed 2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors

Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions. A process to make the 2,3-benzodiazepine derivatives includes converting starting compounds which are substituted by one or two halogen groups and have the general formula ##STR2##

2,3-Benzodiazepine Derivatives as non-competitive AMPA

3-substituted 3H-2, 3-benzodiazepine derivatives, the production and use

This invention relates to new 3-(hydroxymethyl)-isoquinoline derivatives of the general formula (I), their acid addition salts, and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R and R.sup.1 are identical or different and stand for a hydrogen or halogen atom, a nitro or a C.sub.1-4 alkoxy group,

3-(hydroxymethyl)-isoquinoline derivatives

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Budapest, Hungary

Istvan Ling