Egyt Gyogyszervegyeszeti Gyar

Istvan Koczka

Istvan Horvath

Laszlo Tvos

Attila Szemzo

Janos Sagi

Janos Nagy

Anna Szabolcs Nee Borbas

Csilla Rethati

Pal Ivan

Ildiko Fritzsche Nee Lukacs

Maria Peredy Nee Kajtar

The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, ##STR1## wherein R.sup.1 stands for a hydrogen atom, C.sub.1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C.sub.1-4 alkyl group or a halogen atom, and a process for preparing them by brominating 2',3',5'-tri-O-acyl-5-ethyl-uridine of general formula IV, ##STR2## wherein R is identical with R.sup.1, except where R.sup.1 stands for a hydrogen atom, dehydrohalogenating the resulting dibromo compound of general formula V ##STR3## and optionally deacylating it. The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity.

Process for the preparation of 5-(2-bromovinyl)-uridine

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Budapest, Hungary

Istvan Koczka