Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Chinoin Gyogyszer Rt

Istvan Jelinek

Eva Somfai

Gyorgy Lugosi

Laszlo Simandi

Istvan Turcsan

Janos Bodnar

Lajos T Nagy

Antal Simay

Tamas U Kallay

Vilmos Simonidesz

Erzsebet Szalay

Peter Gyory

Gabor Besenyei

Zsuzsanna Nad

Antal S May

Iren Csaszar Nee Toth

Istvan Csik

Marta Lugosi

Ilona Santa Nee Singola

Process for the preparation of pharmaceutical compositions

The invention relates to a process for the preparation of carbamic acid phenyl esters of the formula (I) ##STR1## by acylating phenol derivatives of the formula (II) ##STR2## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, aralkyl having 7 to 16 carbon atoms which groups can be substituted by one or more alkyl groups,

Process for O-acylating phenol derivatives and acylating compositions

A process is disclosed for preparing a carbamic acid phenyl ester of the formula (I) ##STR1## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, or aralkyl having 7 to 16 carbon atoms, wherein the aryl, cycloalkyl or aralkyl is unsubstituted or substituted by at least one alkyl group having 1 to 8 carbon atoms;

In the production of perparine or papaverine and their hydrochlorides, the formation of impurities in the reaction mixture is suppressed by fractionating a 3,4-di-R-benzyl-cyanide in the presence of an organic base (e.g. pyridine, dimethylformamide, ethylenediamine or triethylamine) followed by hydrogenation with a Raney-nickel catalyst treated with aqueous ammonium carbonate solution. R is methoxy or ethoxy.

Process for the manufacture of pure isoquinoline derivatives

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Budapest, Hungary

Istvan Jelinek