Richter Gedeon Vegyeszeti Gyar Rt

Egis Gyogyszergyar

Biogal Gyogyszergyar

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Egyt Gyogyszervegyeszeti Gyar

Basfaktiengesellschaft

Alkaloida Vegyeszeti Gyar

Gyogyszerkutato Intezet

Gyogyszer- Es Vegyeszeti Termekek Gyara Rt.

Istvan Elekes

Sandor Elek

Istvan Polgari

Laszlo Jaszlits

Endre Kasztreiner

Gyorgy Cseh

Laszlo Tardos

Gyorgy Rabloczky

Ferenc Andrasi

Tamas Hamori

Jeno Korosi

Tibor Lang

Jozsef Borsi

Geza Szilagyi

Andras Varro

Edit Kosa

Maria Kuhar Nee Kurthy

Imre Moravcsik

Pal Berzsenyi

Peter Botka

Peter Matyus

Gabor Zolyomi

Judit Kosary

Zsuzsanna Lang Nee Rihmer

Istvan Tibor Toth

Andrea Maderspach

Jozsef Borsy

Pal Bite

Zsuzsa Huszti

Agnes Kenessey

Gyorgy Magyar

Eszter Diszler

Gyongyi Nagy Nee Csokas

Pal Tolnay

Gyula Horvath

Lajos Toldy

Gabor Ambrus

Tibor Balogh

Katalin Goldschmidt

Zoltan Zubovics

Ilona Bodi

Erzsebet Mago Nee Karacsony

Istvan Ling

Antonia Jekkel

Erno Orban

Geza Schneider

Lajos Farkas

Eva Bozo

Ildiko Kiraly

Lajos Ila

Nandor Makk

Ferene Andrasi

Arpad Lazar

Klara Czako

Judit Sarossy Nee Kincsesy

Eszter Diesler

Krisztina Heltai

Katalin G Horvath

Zsuzsanna L Rihmer

Laszlo Szatmary

Laszlo Czollner

ZSuzanne Lang Nee Rihmer

Gyorgy Rablocsky

Ildiko Pribusz Nee Rapp

Laszlo Kaufer

Judit Kincsessy

Ilona Kovacs, Nee Szabo

Eva Tomori

Eva T Sarudy

Lajos Siklosi

Szilagyi Geza

Andras Divald

Judit Sarossy Nee Kincsessy

Istvan Erczi

Jeno Marosfalvi

The present invention relates to an intravenous pharmaceutical composition comprising cyclosporin as active ingredient. The composition is composed of

Intravenous pharmaceutical composition and process for preparing the same

The invention is directed to 1-(2,6-Dimethyl-Phenyl-amino)-2-Dimethyl-amino-Propane and the pharmaceutical composition thereof useful for the treatment of cardiac rhythm disorders.

New alkylene diamine derivatives

This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R stands for a hydrogen or halogen atom, or a C.sub.1-4 alkoxy group,

1-(hydroxystyrl)-5H-2,3-benzodiazepine derivatives, and pharmaceutical

The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiaz epi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ##STR1## The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). ##STR2## The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy.

1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-b

The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof. The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.

Novel dihydropyridines having calcium antagonistic and antihypertensive

The invention relates to novel 3(2H)-pyridazinone-derivatives of the general formula (I), pharmaceutical compositions containing them and process for their preparation. In the general formula (I) ##STR1## stands for an ethyl or propyl group substituted by a terminal halogen atom or a hydroxyl or NR.sup.1 R.sup.2 group, wherein

3(2H)-pyridazinones and pharmaceutical compositions thereof

This invention relates to new 3-(hydroxymethyl)-isoquinoline derivatives of the general formula (I), their acid addition salts, and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R and R.sup.1 are identical or different and stand for a hydrogen or halogen atom, a nitro or a C.sub.1-4 alkoxy group,

3-(hydroxymethyl)-isoquinoline derivatives

The invention relates to new aminoguanidine derivatives of the general formula (I), ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each represent hydrogen or halogen atom, C.sub.1-4 alkyl, nitro, trifluoromethyl or C.sub.1-4 alkoxy group,

Aminoguanidine compounds, their compositions and pharmaceutical uses

The invention relates to new 5H-2,3-benzodiazepine derivatives and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. The new 5H-2,3-benzodiazepine derivatives of the invention possess valuable central nervous effect and in particular exert antiaggressive, anxiolytic, narcosis potentiating and soporific properties.

5H-2,3-benzodiazepine derivatives and pharmaceutical compositions

4-[(3,4-Dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives having the formula I ##STR1## wherein R.sup.1 stands for a cycloalkyl group containing from 3 to 6 carbon atoms or benzyl group;

Anorexigenic 4-[(3,4-dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives

Pyridazinylhydrazones capable of lowering blood pressure have the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;

Novel pyridazinylhydrazones and method of administering same

Pyridazinylhydrazones capable of lowering blood pressure having the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;

Morpholino pyridazinylhydrazones

3-(1-Pyrazolyl)-pyridazine derivatives of the formula I, or pharmaceutically acceptable acid addition salts thereof, which decrease high blood pressure and inhibit catabolism or prostaglandins, ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-4 alkyl,

3-(1-Pyrazolyl)-pyridazine derivatives

The invention relates to compounds of general formula ##STR1## wherein R.sup.1 stands for a hydrogen atom or a C.sub.1-6 alkyl-, a C.sub.2-4 hydroxyalkyl, a C.sub.3-6 cycloalkyl or a phenyl group,

3-(1-Pyrazolyl)-pyridazine derivatives and hypotensive compositions

2-phenoxy-, 2-phenylthio-, and 2-phenylamino-alkyl-2-oxazolines suitable for pharmaceutical use as hypolipemic and hypocholestric agents are disclosed.

2-Phenoxy and 2-phenylthio and 2-phenylamino-alkyl-2-oxazolines

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Budapest, Hungary

Istvan Elekes