Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Astra Aktiebolag

Aktiebolaget Astra

Istvan Bone

Dezso Korbonits

Pal Kiss

Gergely Heja

Endre Palosi

Ida Szvoboda Nee Kanzel

Csaba Gonczi

Csaba Huszar

Laszlo Ledniczky

Erzsebet Szalay

Erzsebet Molnar Nee Bako

Attila Nemeth

Ferenc Morasz

Ferenc Sperber

Karoly Ban

Karol Gyure

Erzsebet Szabo Nee Kardos

Sandor Garaczy

Gyorgy Mihalovics

Andras Szego

Ferenc Kovats

Viktoria Peterdi

Ferenc Z

Iidiko Buttkai

Arpad K Vari

Peter Gy Ri

Mihaly Sut

Peter Gyri

Ildiko Buttkai

Arpad Kvari

Laszlo Gombos

Mihaly Su

Imre Simon

Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and

The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.

The invention relates to a new process for the preparation of stable aqueous suspensions of methyl N-(2-benzimidazolyl)carbamate. According to the invention an aqueous solution of an addition salt of methyl N-(2-benzimidazolyl)carbamate and an inorganic acid, optionally containing an excess amount of acid is reacted with an aqueous potassium, sodium or ammonium hydroxide solution or ammonia gas, in the presence of a wetting, dispersing and antifoaming agent and optionally of a protecting colloid at a temperature of 50.degree. C. to 100.degree. C., and if desired, the suspension obtained is concentrated or diluted. The suspension prepared by this process can either be used directly or can be supplemented with further additive(s) conventionally used in the preparation of plant protecting agents.

Process for the preparation of stable aqueous suspensions of methyl

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Istvan Bone