Eisai Company, Limited

Issei Ohtsuka

Kenji Hayashi

Tadashi Sato

Satoru Tanaka

Hironori Ikuta

Tsuneo Wakabayashi

Toshinobu Kunii

Hironobu Hiyoshi

Toshiharu Ohgoh

Mayumi Kawase

Kengo Kagei

Kouichiro Ueda

Shinya Abe

Shigeru Souda

Katsuya Tagami

Nobuhisa Watanabe

Hiroshi Tanaka

Yoshio Fukuda

Hideki Ono

Naoki Kobayashi

Makoto Kaino

Yoshihito Eguchi

Makoto Nakagawa

Ichirou Yoshida

Isao Saito

Teiji Kimura

Youji Yamagishi

Kozo Akasaka

Tohru Fujimori

Takao Saeki

Yasutaka Takase

Toru Horie

Makoto Matsui

Motoji Kogushi

Hiroko Kobayashi

Koichi Nose

Ono Hideki

Motoji Kokushi

Toshie Yamada

Phosphonic acid derivatives

A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. ##STR1## wherein R.sup.1 stands for a lower alkyl group, an amino group which may be substituted, or the like; R.sup.2 stands for a group represented by the formula: ##STR2## (wherein R.sup.16 stands for an alkyl group having 1 to 6 carbon atoms, or the like) or the like; R.sup.3 stands for a group represented by the formula: --O--(CH.sub.2).sub.m --Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R.sup.5 stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: ##STR3## (wherein R.sup.6 stands for a hydrogen atom, a lower alkyl group, or the like), --N.dbd., or the like; and B stands for a group represented by the formula: ##STR4## (wherein R.sup.4 stands for a hydrogen or the like), --N.dbd., or the like.

Trisubstituted benzene derivatives, composition and methods of treatment

Benzene derivatives and method of treating arteriosclerosis with benzene

Phosphorus-containing isoprenoid derivatives

Novel hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, mean independently hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; Y means oxygen atom or sulfur atom, R.sub.1 and R.sub.2, which may be the same or different, mean independently hydrogen atom, a lower alkyl group or phenyl group, or the both may form a ring with a carbon atom which is combined with them, excluding the case wherein both R.sub.1 and R.sub.2 are hydrogen atom at the same time, and n means an integer of 0 or 1. The novel hydantoin derivatives and salts thereof have excellent effects for the treatment of the complications of the diabetes mellitus.

Hydantoin derivatives and medicines containing the same

Hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein the substituents are defined hereinbelow. The hydantoin derivatives and salts thereof have excellent effects for the treamtment of the complications of the diabetes mellitus.

Hydantoin derivatives for treating complications of diabetes

Novel hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, independently represent a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; Y represents an oxygen atom or sulfur atom, R.sub.1 and R.sub.2, which may be the same or different, independently represent a hydrogen atom, a lower alkyl group or phenyl group, or both may form a ring with carbon atoms, excluding the case wherein both R.sub.1 and R.sub.2 are hydrogen atom, and n represents 0 or 1. The novel hydantoin derivatives and salts thereof have excellent effects for the treatment of the complications of diabetes mellitus.

Treating complications of diabetes mellitus with hydantoin derivatives

Growing community of inventors

Ibaraki, Japan

Issei Ohtsuka