Fujifilm Corporation

Toyama Chemical Co., Ltd.

Fujifilm Toyama Chemical Co., Ltd.

Issei Doi

Masahiko Yamamoto

Taisuke Endo

Motomasa Takahashi

Hirofumi Fukunaga

Kimihiko Sato

Shintaro Tanabe

Kazuhiro Tsuna

Yasutaka Tasaki

Daisuke Nakagawa

Tadashi Tanaka

Tatsuya Murakami

Takayuki Yamakawa

Masataka Fujino

Yoshitake Konishi

Daisuke Kubo

An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents —NR— or —O—, Rrepresents a hydrogen atom, a hydrocarbon group, or the like, Rand Reach independently represent a hydrogen atom, a hydrocarbon group, or the like, R, R, R, R, R, R, R, R, and Reach independently represent a hydrogen atom or an alkyl group,

Compound or salt thereof and lipid particles

A novel amine derivative expressed by general formula (1) (in the formula: G, G, and Gare the same or different and represent CH or a nitrogen atom; Rrepresents a chlorine atom, an optionally-substituted Ccycloalkyl group, or the like; Rrepresents &#x2014;COOR(in the formula, Rrepresents a hydrogen atom or a carboxyl protective group), or the like; Rrepresents a hydrogen atom, or the like; and Rrepresents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.

Amine derivative or salt thereof

Growing community of inventors

Toyama, Japan

Issei Doi