Glaxo Group Limited

Shionogi Company Limited

Israil Pendrak

Neil David Pearson

William Henry Miller

Robert A Daines

Mark Andrew Seefeld

Graham Elgin Jones

David Thomas Davies

Timothy Francis Gallagher

Jeffrey Michael Axten

Xiangmin Liao

Jun Sato

Alan Joseph Hennessy

Toshiaki Aoki

Steven Dabbs

Kenji Yamawaki

Timothy James Miles

Gerald Brooks

Masayuki Sano

Julia Castro Pichel

Jose Maria Fiandor Roman

Hiroki Kusano

Katsuki Yokoo

Lluis Ballell

Reema K Thalji

Lihua Zhang

Lihua(lily) Zhang

James B Hoffman

Jason Anthony Rossi

Modesto J Remuiñan Blanco

David Barros

Reema Thalgi

Ilaria Giordano

Modesto J Remuinan Blanco

The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

2 substituted cephem compounds

The present invention relates to cephalosporin antibacterial compounds of Formula (I): or corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.

Antibacterial compounds

Bicyclic nitrogen containing compounds and their use as antibacterials.

Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones

Compounds of formula (I) and derivatives thereof: compositions containing them, their preparation and their use as antibacterials.

Antibacterial agents

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.

Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. The piperidine derivatives include compounds of formula (I): wherein R, AB, n, R, Rand Rare defined herein. For example, Ris an optionally substituted bicyclic carbocyclic or heterocyclic ring system, and Ris a group U-Rin which Ris an optionally substituted bicyclic heterocyclic ring system as defined herein (e.g. optionally substituted pyrido [3,2, -b][1,4] thiazin-yl).

Compounds

Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.

Aminopiperidine derivatives

Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.

Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them

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Collegeville, PA, United States of America

Israil Pendrak