Advanced Biodesign

Ismail Ceylan

Guillaume Martin

Gerry Quash

Mileidys Perez-Alea

Guy Fournet

Gérard Quash

Milleidys Perez-Alea

Axelle Berrou

Mileidys Perez

The invention relates to a specific substrate on an ALDH isoenzyme, to a composition comprising at least one such substrate, to a diagnostic marker comprising such a substrate, and to the uses thereof and associated methods.

Specific substrate of an ALDH isoenzyme

The present invention concerns an ex vivo method for the monitoring of apoptosis which is based on the detection of free gamma-glutamyl-L-epsilon-Lysine (GGEL) in a biological sample of a subject with a monoclonal antibody specific to GGEL. The invention also relates to the monoclonal antibody specific to GGEL, as well as to diagnostic kits containing such a ligand.

Monoclonal antibody specific for gamma-glutamyl-l-epsilon-lysine for the monitoring of apoptosis

The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase HOlevel in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce HOin comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.

Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H2O2 level in cancer cells of a subject

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Saint-Priest, France

Ismail Ceylan