Hoechst Aktiengesellschaft

Ismahan Okyayuz-Baklouti

Dirk Seiffge

Rolf Graeve

Ulrich Gebert

Stefan Mullner

Werner Thorwart

Harald Furrer

Hiristo Anagnostopulos

John J Grome

Gunter Billen

Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their use as pharmaceuticals A compound of the formula ##STR1## where R.sup.1 and R.sup.3 are identical or different and at least one of the radicals R.sup.1 and R.sup.3 is a radical of the formula XI ##STR2## in which E is a covalent bond or a (C.sub.1 -C.sub.5)-alkyl, are suitable for the production of pharmaceuticals for the treatment of muscular atrophy, cachexia, muscular dystrophy, sepsis, septic shock, endotoxic shock, systemic inflammation response syndrome, adult respiratory distress syndrome, cerebral malaria, chronic pneumonia, pulmonary sarcoidosis, reperfusion damage, scar formation, inflammation of the bowel and ulcerative colitis, as a result of infections, acquired immune deficiency syndrome, cancer, trauma and other disorders having increased protein loss, peripheral circulatory disorders, disorders having altered leucocyte adhesion, and also disorders which are accompanied by an increased or unregulated tumor necrosis factor production such as rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis and other arthritic disorders.

Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their

Pyridopyrimidinediones, processes for their preparation and their use as drugs A compound of the formula I: ##STR1## and/or physiologically acceptable salts of the compound of the formula I, and/or optionally stereoisomeric forms of the compound of the formula I, are suitable for the preparation of drugs for the treatment of circulatory disorders and/or neurodegenerative diseases.

Pyridopyrimidinediones, processes for their preparation and their use as

Imidazole compounds of the formula I ##STR1## in which R.sup.1 =alkyl,

Imidazole compounds, processes for their preparation, pharmaceuticals

Tertiary hydroxyalkylxanthines, medicaments containing them and their use

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Wiesbaden, Germany

Ismahan Okyayuz-Baklouti