Centro De Ingenieria Genetica Y Biotecnologia

Centro De Ingenieria Genetica Y Biotechnologia

Isis Del Carmen Torrens Madrazo

Julio Raul Fernandez Masso

Ariana Garcia Ojalvo

Jose De La Fuente Garcia

Alina Seralena Menendez

Elder Pupo Escalona

Martha De Jesus Gonzalez Griego

Osvaldo Reyes Acosta

Boris Ernesto Acevedo Castro

Maribel Guerra Vallespi

Milaid Granadillo Rodriguez

The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein(LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.

Cell penetrating peptides and its use fused to biomolecules with therapeutic action

Streptokinase mutants

The present invention is related to the field of biotechnology and genetic engineering techniques, particularly to a method for obtaining mutants obtain from streptokinase, to the molecules obtained from this method, as well as the expression vectors and microorganisms for recombinant obtaining. The object of the present invention is to achieve streptokinase mutants from modifications of skc-2 gene coding for streptokinase SKC-2 (Heberkinase&reg;), such that the obtained mutants conserve their capacity for plasminogen activator complex formation having reduced antigenicity, that could constitute preferred alternatives to native streptokinase for thrombolytic therapy. The molecules obtained from present invention can be used in the treatment of disorders as myocardial infarct, pulmonary thromboembolism, surgical complications and other cases of thrombosis.

Growing community of inventors

Ciudad de la Habana, Cuba

Isis Del Carmen Torrens Madrazo